Registered Nurse Jobs in South Carolina
Across 123 live Registered Nurse listings in South Carolina, median advertised pay is $106K (75th percentile $113K), based on the 28 that state a salary; South Carolina ranks 37th of 51 states by median advertised pay; the employers with the most openings are MUSC (14), Pruitt Health (13), Prisma Health (12).
123+ positions available
Figures are computed from live listings and reviewed by WeekdayDoc’s physician-led editorial team; data as of November 6, 2026. Posted ranges, not accepted offers. How we compute this
These 28 roles pay ~$106k median with 4.8/10 median work-life balance — use these as your benchmarks.
Structural Heart Nurse Navigator
Self Regional HealthcareGreenwood, SC
Registered Nurse (RN) - Navigator Ambulatory, General Surgery, FT, Day
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Registered Nurse Pay in South Carolina: Live Market and State Comparison
Live registered nurse listings in South Carolina today, then South Carolina against neighboring states and the top payers over the last 12 months of our own postings — so every state is measured alike. Not a salary survey.
- Live listings
- 123
- Live median
- $106k
- 75th $113k · n=28
- 12-mo median
- $89k
- Pay rank
- #37 of 51
- Work-life
- 4.0/10 · #45
- 12-mo postings
- 470
Registered Nurse roles in South Carolina advertise $4k below the $93k median across the 51 states we can measure, where Wyoming leads at $122k.
| State | Median pay (12 mo) | vs SC | WLB | Postings (12 mo) |
|---|---|---|---|---|
| South Carolina (this page) | $89k | — | 4.0/10 | 470 |
| Wyoming#1 | $122k | +$33k | 4.6/10 | 26 |
| Hawaii#2 | $122k | +$33k | 4.8/10 | 39 |
| California#3 | $121k | +$31k | 4.3/10 | 1355 |
| Washington#4 | $116k | +$27k | 4.4/10 | 318 |
| Oregon#5 | $114k | +$25k | 4.5/10 | 159 |
| Georgiaborders | $92k | +$3k | 4.1/10 | 1073 |
| North Carolinaborders | $84k | −$5k | 4.8/10 | 914 |
“borders” = shares a border with South Carolina; “#n” = national pay rank among the 51 measured states. Live figures count the listings on WeekdayDoc today (updated Nov 6, 2026); 12-month figures include postings since closed, so states compare on the same basis.
- Most openings on this page:
- MUSC (14), Pruitt Health (13), Prisma Health (12)
- Sign-on & loan repayment:
- 10% state a sign-on bonus · 8% offer loan repayment (of 123 live listings on this page)
- Top-rated employers hiring:
- Talkiatry (gold, 95/100), Hiaah (gold, 95/100), BetterHelp (gold, 93/100) (Top Employers work-life index)
A few things worth knowing
About Registered Nurse jobs in South Carolina.
How much do registered nurses earn in South Carolina?
A reliable salary estimate is unavailable for this sample of registered nurses. Compensation varies by role, specialty, location, and schedule. Compare employer-posted pay where disclosed, including its currency and pay period; missing pay is not estimated.
Are there remote or hybrid registered nurse jobs available?
Yes — about 5% of current registered nurses listings offer remote or hybrid work. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.
Which registered nurse jobs have the best work-life balance?
Every registered nurse role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 10% with no on-call and 55% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.
Who is hiring registered nurses in South Carolina right now?
Employers currently hiring for registered nurse roles include Crescent Hospice, Roper St. Francis Healthcare, Prisma Health, Science 37, and others. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.
How many registered nurse jobs in South Carolina are available, and how often are they updated?
There are currently 123 registered nurses positions in South Carolina listed, with new roles added as employers post them. Job descriptions are public. Verified sign-in with Google or email gives free access to regular Apply, full search, and standard Market Insights. Saved jobs, My Search, and the dashboard also require verified sign-in. Eligible featured employer listings allow Apply without signup or email. Basic calculators are public and free; optional AI contract analysis, RVU Billing Optimizer, and Schedule Optimizer reports remain paid.
Employers hiring now
Organizations with the most openings in Registered Nurse Jobs in South Carolina
MUSC14 open roles here · WLB 59/100
Pruitt Health13 open roles here · WLB 73/100
McLeod Health11 open roles here · WLB 75/100
Crescent Hospice6 open roles here · WLB 53/100UHS5 open roles here · WLB 64/100
Unifi Healthcare5 open roles here · WLB 73/100
Roper St. Francis Healthcare4 open roles here · WLB 40/100