ICON plc logo
ICON plc
San Antonio, Texas

Clinical Research Nurse I

Registered NurseNo weekendsNo nightsFull-Time

Compensation

Pay not listed

The week · per this posting · Monday – FridayWeekdays only

Ask the employer about the pay range, call expectations and time off.

Posted 1mo ago

Job Description

Opening Headline Clinical Research Nurse I- Ft Perm M-F Day Shift- ICON San Antonio TX

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

  • Title: Clinical Research Nurse I
  • Location: 100% on site San Antonio TX- 78232
  • Shift/Schedule: Monday - Friday 6AM-2:30 PM

What You Will Do

You will play a pivotal role in supporting the execution of clinical trials, ensuring adherence to protocol requirements, and providing compassionate patient care throughout the research process.

Key Responsibilities Include

Assisting in the planning, implementation, and coordination of clinical research activities in accordance with study protocols, regulatory guidelines, and standard operating procedures (SOPs).

Conducting patient assessments, administering study treatments, and performing clinical procedures as required by the research protocol, while ensuring patient safety and compliance with ethical standards.

Collecting, recording, and maintaining accurate and complete data documentation, including medical histories, vital signs, adverse events, and laboratory results, in electronic case report forms (eCRFs) and study databases.

Collaborating with multidisciplinary teams, including investigators, study coordinators, and regulatory staff, to ensure efficient study conduct, participant recruitment, and retention throughout the duration of the trial.

Providing education and counseling to study participants and their families regarding study procedures, treatment regimens, and informed consent, while addressing any questions or concerns that may arise during the course of the study.

Your Profile

Must hold a current and valid Registered Nurse (RN) license in the state of Texas.

Minimum of 2 years of clinical nursing experience, preferably in a research or academic healthcare setting, with exposure to clinical trial operations and Good Clinical Practice (GCP) guidelines.

Strong clinical assessment and critical thinking skills, with the ability to recognize and respond to changes in patient status and communicate effectively with healthcare professionals and study investigators.

Knowledge of regulatory requirements governing clinical research, including the International Council for Harmonization (ICH) guidelines and local regulatory requirements, with a commitment to upholding ethical standards and patient confidentiality.

Proficiency in electronic medical record (EMR) systems, clinical documentation, and data entry, with a high level of attention to detail and accuracy in recording patient information and study data.

Excellent interpersonal and organizational skills, with the ability to work independently and collaboratively in a fast-paced, multidisciplinary environment, while prioritizing competing demands and meeting project deadlines.

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits May Include

  • Competitive base salary and performance related incentives
  • Health and wellbeing programmes including medical, dental, and vision coverage where applicable
  • Retirement and pension plans
  • Life assurance and disability coverage
  • Employee assistance programmes and wellbeing resources
  • Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

Visit our careers site to read more about the benefits ICON offers.

Inclusion and Accessibility

ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.

If you require reasonable accommodations during the recruitment process, please let us know or submit a request here.

Are you a current ICON Employee? Please click here to apply

Key Responsibilities

The Clinical Research Nurse will support the execution of clinical trials by ensuring adherence to protocols and providing compassionate patient care. Responsibilities include conducting patient assessments, administering treatments, and maintaining accurate data documentation in electronic case report forms.

Requirements

Candidates must hold a current and valid Registered Nurse (RN) license in the state of Texas. A minimum of 2 years of clinical nursing experience, preferably in a research or academic setting, is required along with knowledge of Good Clinical Practice (GCP) guidelines.

Qualifications

Experience
2+ years of experience

Key Skills

Protocol adherencePatient assessmentRegulatory complianceElectronic medical recordsInterpersonal skillsPatient educationMultidisciplinary collaboration

Ambulatory Care Nursing — Registered Nurse Career Context

Of the 50 active Ambulatory Care Nursing listings this role was benchmarked against, 28% are remote, 50% have no call, 86% require no weekends.

The cost-of-living index for Texas is 97.1 (US average = 100; BEA Regional Price Parities (2024)). 57.7% of Texas clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

Ambulatory Care Nursing pay on WeekdayDoc is down 1.1% vs. the prior quarter (through Sep 2026).

Work-Life Balance Analysis

WeekdayDoc's proprietary algorithm rates Clinical Research Nurse I at ICON plc a 6.4 out of 10 for work-life balance — classified as good. This places the position in the top 25% in Ambulatory Care Nursing (RN) — ranked against 387 active Ambulatory Care Nursing (RN) listings on WeekdayDoc. Contributing factors include no weekend requirements, no night shifts.

Location & Logistics

Texas has no state income tax, which can significantly increase take-home pay compared to high-tax states.

Top Registered Nurse Jobs

37 matches · ranked by pay

Salary Distribution36 jobs · 33 employers

10
<$95k
10
$95k-110k
5
$110k-125k
6
$125k-140k
5
$140k+

Annual compensation range

Benefits & Perks29 jobs

401k / retirement match
97% this job
Sign-on bonus
17%
Loan repayment
7%
CME allowance
3%

Share of similar jobs offering each benefit

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Inova Health System · Falls Church, Virginia

$93k-$151k
#2

Asst. Director of Nursing - Ambulatory Care - Newkirk Avenue

Maimonides Medical Center · Brooklyn, New York

$136,708 - $150,000
#3

Assistant Director of Nursing

$128k-$142k
#4

Utilization Review Registered Nurse - 40 hours

$39-$68.25/hr
+ 35 more · ranked by pay

Work-life snapshot

median 5.1this job 6.4
Better work-life than 80% of Ambulatory Care Nursing (RN) listings

Listing-based score, 0–10, across 387 comparable listings. Shaded area = the share scoring below this one.

  • No weekends
  • No nights
  • On-site

Living in San Antonio

Typical 3-bedroom home value
$226k
Typical market rent
$1,386/mo
Residents’ average commute
25 min
Metro price indexU.S. average = 100
94.7
State income tax
None
Sources & methodology

Sources: Zillow home values (Aug 2026), Zillow market rents (Aug 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · San Antonio-New Braunfels, TX metro prices. Housing figures are city-level.

City-level figures. Not a cost-of-living guarantee.

ICON plc logo

About ICON plc

Biotechnology Research
Dublin
10,000+ employees

Benefits & Perks

Competitive base salary
Performance related incentives
Medical, dental, and vision coverage
Retirement and pension plans
Life assurance and disability coverage
Employee assistance programmes
Learning and development opportunities