One Oncology logo
One Oncology
Orange, California

Lead Physician Assistant

Physician AssistantFull-Time

Listed compensation

$150k-$210k

The week · per this posting · weekdays assumed

Ask the employer about the work setting, call expectations, weekend coverage and time off.

Posted 1h ago · Verified live

Job Description

The mission of The Los Angeles Cancer Network is to provide unparalleled care to each patient that comes through our doors. We offer individualized treatment using the most recent and relevant proven advances in cancer care, curated with deliberation and compassion.

LACN is committed to educating and supporting our patients and their families through every step of the way. We deliver a unique approach for every patient to ensure they receive treatment best suited to their condition, age, and other important factors.

We do this by participating in important clinical research, encouraging screenings for early detection, and providing innovative treatment. We are proud to be at the forefront of cancer research through our partnership with OneOncology.

Why Join Us? We are looking for talented and highly-motivated individuals who demonstrate a natural desire to support the meaningful work of community oncologists and the patients we serve.

Job Description

  • Lead Physician Assistant
  • Location: Orange, California
  • Employment Type: Full-Time

We are seeking an experienced and motivated Lead Physician Assistant to join our growing oncology practice in California. This leadership role is ideal for a skilled Physician Assistant with a strong background in oncology, a commitment to exceptional patient care, and the ability to support clinical operations and collaborate with physicians and multidisciplinary care teams.

The Lead Physician Assistant will provide clinical leadership, support the delivery of high-quality oncology care, and help promote consistency in clinical practices, patient management, and team collaboration.

Key Responsibilities

Provide comprehensive patient assessments, evaluations, and follow-up care for patients with cancer and hematologic conditions.

Collaborate closely with oncologists, hematologists, nurses, and other healthcare professionals to develop and implement individualized treatment plans.

Support the management of patients receiving chemotherapy, immunotherapy, and other oncology treatments within the scope of practice.

Provide clinical leadership, mentorship, and guidance to Physician Assistants and other clinical team members, as applicable.

Assist with the coordination of patient care, including reviewing diagnostic results, monitoring treatment responses, and managing treatment-related symptoms and complications.

Promote adherence to established clinical protocols, quality standards, patient safety practices, and applicable regulatory requirements.

Support the development and implementation of clinical workflows, operational improvements, and best practices.

  • Coordinate patient transitions, referrals, and communication among providers to ensure continuity of care.
  • Educate patients and families regarding diagnoses, treatment options, medication management, and supportive care.
  • Maintain accurate and timely clinical documentation in the electronic health record.
  • Participate in quality improvement initiatives, clinical meetings, and other practice leadership activities.
  • Perform other related duties as assigned.

Qualifications

  • Master’s degree from an accredited Physician Assistant program.
  • Current and active California Physician Assistant license in good standing.
  • Demonstrated experience in medical oncology, hematology, or a related specialty; oncology experience strongly preferred.
  • Prior clinical leadership, mentoring, or supervisory experience preferred.
  • Strong clinical judgment and the ability to manage complex patient care needs in collaboration with the supervising or collaborating physician, as applicable.
  • Excellent communication, interpersonal, organizational, and problem-solving skills.
  • Ability to work effectively in a fast-paced, multidisciplinary outpatient oncology environment.
  • Commitment to compassionate, patient-centered care and clinical excellence.
  • Proficiency with electronic health records and clinical documentation.

Compensation

The starting annual salary range for this full-time position is $150,000–$210,000, depending on qualifications, relevant experience, and other job-related factors.

Why Join Our Team?

Join a collaborative oncology practice where clinical expertise, leadership, and compassionate patient care make a meaningful difference in the lives of patients and their families. This is an opportunity to contribute to clinical excellence while helping strengthen the delivery of specialized oncology care.

Qualifications

Experience
5+ years of experience

Key Skills

Patient assessmentTreatment planningChemotherapy managementPatient educationSymptom managementMultidisciplinary collaborationRegulatory compliance

Oncology — Physician Assistant Career Context

Of the 50 active Oncology listings this role was benchmarked against, 10% are remote, 62% have no call, 68% require no weekends.

The cost-of-living index for California is 110.7 (US average = 100; BEA Regional Price Parities (2024)), so the posted ~$180k midpoint carries the purchasing power of roughly $163k in an average-cost state. 63.6% of California clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

Oncology by the numbers
MeasureThis jobMarket
Listed pay$150k–$210kOncology median $126k (middle half $110k–$155k)36 comparable listings, Oct 2026
Cost-of-living adjusted pay~$163k in purchasing powerCalifornia index 110.7 (US = 100)BEA Regional Price Parities (2024)
Oncology listings in California11 active91 nationallylive on WeekdayDoc, Oct 2026
Work settingon-sitepeers: 10% remote · 62% no call · 68% no weekends50 benchmarked listings
Sources: WeekdayDoc live listing index, BEA Regional Price Parities (2024); as of Oct 2026. Same values as the Weekday Verdict and Market Insights on this page.

Top Physician Assistant Jobs

38 matches · ranked by pay

Salary Distribution

38 jobs · 30 employers
7
<$145k
4
$145k-165k
17
$165k-185k
8
$185k-205k
2
$205k+

Annual compensation range

Benefits & Perks

33 jobs · 30 employers
401k / retirement match
85%
CME allowance
67%
Sign-on bonus
55%
Relocation assistance
15%
Loan repayment
9%

Share of similar jobs offering each benefit

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Work-life snapshot

median 3.9this job 1.5
Below most Oncology (PA) listings for work-life

Listing-based score, 0–10, across 88 comparable listings. Shaded area = the share scoring below this one.

One Oncology logo

About One Oncology

Hospitals and Health Care
Nashville, Tennessee
501-1,000 employees

Benefits & Perks

Competitive salary
Benefits package

Living in Orange

Typical 3-bedroom home value
$1.04M≈ 7.0× annual pay
Typical market rent
$3,037/mo≈ 24% of gross pay
Residents’ average commute
26 min
Metro price indexU.S. average = 100
113.6
State income tax
Up to 13.3%
Sources & methodology

Sources: Zillow home values (Sep 2026), Zillow market rents (Sep 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · Los Angeles-Long Beach-Anaheim, CA metro prices. Housing figures are city-level.

Ratios use this listing’s gross annual pay. Not a cost-of-living guarantee.