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47+ Nurse Practitioner Jobs in South Dakota

Nurse Practitioner positions in South Dakota with $100K-$150K salary ranges, burnout scores, and schedule details shown upfront. Filter by no call, remote, and weekday-only.

47+ positions available

47+ Nurse Practitioner Jobs in South Dakota Available Now

These 7 roles pay ~$157k median with 6.1/10 median work-life balance — use these as your benchmarks.

Sanford Health logo

APP - Pediatric Nurse Practitioner | Pediatrics

Sanford Health

No Nights
Avera Health logo

Nurse Practitioner | Hospice | PRN

Avera Health

No Nights
Above avg

in Hospice And Palliative Medicine (NP)

Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | Family Medicine

Sanford Health

No Nights
Avera Health logo

Physician Assistant or Nurse Practitioner | Gastroenterology

Avera Health

No Nights
Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | Orthopedics & Sports Medicine

Sanford Health

No NightsNo Weekends
Above avg

in Orthopedic Surgery (NP)

Avera Health logo

Nurse Practitioner or Physician Assistant | Oncology Service Line

Avera Health

No Nights
Avera Health logo

Nurse Practitioner or Physician Assistant I Medical Oncology

Avera Health

No Nights
Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | Acute Care

Sanford Health

No Nights
Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | Cardiovascular & Thoracic Surgery

Sanford Health

No Nights
Above avg

in Surgery (NP)

Sanford Health logo

Nurse Practitioner, Vascular Surgery

Sanford Health

No CallNo Nights
Top 25%

in Surgery (NP)

Sanford Health logo

APP - Pediatric Nurse Practitioner | Pediatric Surgery

Sanford Health

No Nights
Above avg

in Surgery (NP)

Sanford Health logo

APP - Physician Assistant or Nurse Practitioner | Interventional Pain Management

Sanford Health

No Nights
Sanford Health logo

Physician Assistant or Nurse Practitioner | Podiatry

Sanford Health

No CallNo Nights
Top 10%

in Nurse Practitioner roles

Sanford Health logo

Nurse Practitioner II, Orthopedic Surgery

Sanford Health

No Nights
Top 25%

in Orthopedic Surgery (NP)

Sanford Health logo

APP - Physician Assistant or Nurse Practitioner | Surgery

Sanford Health

No Nights
Above avg

in Surgery (NP)

A nurse practitioner in south dakota role paying $104K - $124.8K is hidden in this list.

46 more hidden below, ranked by pay and work-life.

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Nurse Practitioner

Sioux Falls, South Dakota104K - $124.8K
+ 46 more · up to $104K - $124.8K

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How South Dakota Compares for Nurse Practitioner Pay

South Dakota against neighboring states and the top payers, from our own nurse practitioner postings over the last 12 months — not a salary survey.

Median advertised
$117k
Pay rank
#51 of 51
Work-life balance
5.0/10 · #45
Open listings
63

Nurse Practitioner roles in South Dakota advertise $19k below the $137k median across the 51 states we can measure, where North Dakota leads at $191k.

Nurse Practitioner median pay and work-life-balance score, South Dakota compared with neighboring states and the highest-paying states
StateMedian payvs SDWLBListings
South Dakota (this page)$117k5.0/1063
North Dakotaborders$191k+$74k4.9/108
Alaska#2$181k+$63k6.0/1020
Wyomingborders$172k+$54k6.6/1012
Minnesotaborders$140k+$23k5.4/10203
Montanaborders$140k+$22k5.1/1038
Nebraskaborders$136k+$18k4.5/1060
Iowaborders$127k+$10k5.6/10129

“borders” = shares a border with South Dakota; “#n” = national pay rank among the 51 measured states.

Nurse Practitioner Jobs in South Dakota: Market Overview & Work-Life Balance

South Dakota offers a competitive market for healthcare professionals seeking nurse practitioner jobs in south dakota. With 47+ open positions, clinicians have strong options for career growth and work-life balance.

Every listing is evaluated using WeekdayDoc's proprietary work-life balance scoring system. Nurse Practitioner Jobs in South Dakota on this page have an average score of 5.5/10, with 17% with no on-call requirements, 17% with no weekends. This data helps clinicians quickly identify positions that match their lifestyle priorities without reading through hundreds of job descriptions.

Leading employers currently hiring for nurse practitioner jobs in south dakota include Sanford Health, Avera Health. Positions span nurse practitioner jobs south dakota. New jobs are added daily as healthcare organizations expand their teams.

Among the top-rated employers hiring for nurse practitioner jobs in south dakota, Talkiatry (score: 95.8/100), Up Lift (score: 94.5/100), Cyti Clinics (score: 94.5/100) have earned WeekdayDoc's Top Employer designation based on our proprietary ranking system. This ranking evaluates burnout scores (40%), salary competitiveness (30%), and work-life balance features like no-call and remote options (30%). See the full rankings on our Top Employers page.

According to WeekdayDoc's Market Pulse — which tracks real-time compensation data from thousands of active job postings — the current median salary is $101K, trending down 4.9% over the past quarter. This data is derived from 7,451+ job postings analyzed over the past 12 months — updated daily, unlike annual survey-based reports. Explore salary trends and burnout data on our Market Pulse dashboard.

Frequently Asked Questions

How much do nurse practitioners earn in South Dakota?

Nurse practitioner salaries typically range from $100K–$150K annually, depending on specialty, location, and experience. WeekdayDoc shows the posted pay on every listing so you can compare before applying.

Are there remote or hybrid nurse practitioners jobs available?

Some nurse practitioners roles offer remote or hybrid flexibility. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.

Which nurse practitioners jobs have the best work-life balance?

Every nurse practitioner role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 17% with no on-call and 17% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.

Who is hiring nurse practitioners in South Dakota right now?

Employers currently hiring for nurse practitioner roles include Sanford Health, Avera Health. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.

How many nurse practitioner jobs in south dakota are available, and how often are they updated?

There are currently 47+ nurse practitioners positions in South Dakota listed, with new roles added daily as employers post them. Create a free account to compare salaries and work-life-balance scores side by side, then apply directly.

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