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47+ Nurse Practitioner Jobs in South Dakota

Nurse Practitioner positions in South Dakota with $100K-$150K salary ranges, burnout scores, and schedule details shown upfront. Filter by no call, remote, and weekday-only.

47+ positions available

47+ Nurse Practitioner Jobs in South Dakota Available Now

These 7 roles pay ~$157k median with 6.1/10 median work-life balance — use these as your benchmarks.

ENCOMPASS WELLNESS P logo

Nurse Practitioner

Encompass Wellness P

Above avg

in Family Medicine (NP)

Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | Cardiology

Sanford Health

Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | ED and Acute Care

Sanford Health

Horizon Health logo

Nurse Practitioner or Physician Assistant

Horizon HealthGreat Workplace

Above avg

in Family Medicine (NP)

Avera Health logo

Nurse Practitioner | Neonatal

Avera Health

Avera Health logo

Nurse Practitioner or Physician Assistant | Emergency

Avera Health

Sanford Health logo

APP - Physician Assistant or Nurse Practitioner | TRACS

Sanford Health

Commonwealth Medical Services logo

Neurology and Sleep Medicine NP/PA - South Dakota

Commonwealth Medical ServicesGreat Workplace

Commonwealth Medical Services logo

Vascular Medicine Nurse Practitioner/Physician Assistant (NP/PA) - South Dakota

Commonwealth Medical ServicesGreat Workplace

Avera Health logo

Nurse Practitioner or Physician Assistant | Nephrology

Avera Health

Complete Health logo

Certified Nurse Practitioner

Complete HealthGreat Workplace

Above avg

in Family Medicine (NP)

Huron Regional Medical Center logo

Emergency Department - Physician Assistant or Nurse Practitioner

Huron Regional Medical Center

Top 25%

in Emergency Medicine (NP)

Avera Health logo

Nurse Practitioner | Dermatology

Avera Health

No Nights
Sanford Health logo

APP - Nurse Practitioner or Physician Assistant | Occupational Medicine

Sanford Health

No Nights
One to One Health logo

Nurse Practitioner

One to One HealthGreat Workplace

No NightsNo Weekends
Work-life

6.4/10

A nurse practitioner in south dakota role paying $104K - $124.8K is hidden in this list.

46 more hidden below, ranked by pay and work-life.

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Nurse Practitioner

Sioux Falls, South Dakota104K - $124.8K
+ 46 more · up to $104K - $124.8K

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How South Dakota Compares for Nurse Practitioner Pay

South Dakota against neighboring states and the top payers, from our own nurse practitioner postings over the last 12 months — not a salary survey.

Median advertised
$117k
Pay rank
#51 of 51
Work-life balance
5.0/10 · #45
Open listings
63

Nurse Practitioner roles in South Dakota advertise $19k below the $137k median across the 51 states we can measure, where North Dakota leads at $191k.

Nurse Practitioner median pay and work-life-balance score, South Dakota compared with neighboring states and the highest-paying states
StateMedian payvs SDWLBListings
South Dakota (this page)$117k5.0/1063
North Dakotaborders$191k+$74k4.9/108
Alaska#2$181k+$63k6.0/1020
Wyomingborders$172k+$54k6.6/1012
Minnesotaborders$140k+$23k5.4/10203
Montanaborders$140k+$22k5.1/1038
Nebraskaborders$136k+$18k4.5/1060
Iowaborders$127k+$10k5.6/10129

“borders” = shares a border with South Dakota; “#n” = national pay rank among the 51 measured states.

Nurse Practitioner Jobs in South Dakota: Salary, Outlook & Work-Life Balance

South Dakota offers a competitive market for healthcare professionals seeking nurse practitioner jobs in south dakota. With 47+ open positions and salaries ranging from $93K to $157K, clinicians have strong options for career growth and work-life balance.

Every listing is evaluated using WeekdayDoc's proprietary work-life balance scoring system. Nurse Practitioner Jobs in South Dakota on this page have an average score of 4.1/10, with 10% with no weekends. This data helps clinicians quickly identify positions that match their lifestyle priorities without reading through hundreds of job descriptions.

Leading employers currently hiring for nurse practitioner jobs in south dakota include Avera Health, Sanford Health, Commonwealth Medical Services, ENCOMPASS WELLNESS P, and more. Positions span nurse practitioner jobs south dakota. New jobs are added daily as healthcare organizations expand their teams.

Among the top-rated employers hiring for nurse practitioner jobs in south dakota, Talkiatry (score: 95.8/100), Up Lift (score: 94.5/100), Cyti Clinics (score: 94.5/100) have earned WeekdayDoc's Top Employer designation based on our proprietary ranking system. This ranking evaluates burnout scores (40%), salary competitiveness (30%), and work-life balance features like no-call and remote options (30%). See the full rankings on our Top Employers page.

According to WeekdayDoc's Market Pulse — which tracks real-time compensation data from thousands of active job postings — the current median salary is $101K, trending down 4.9% over the past quarter. This data is derived from 7,451+ job postings analyzed over the past 12 months — updated daily, unlike annual survey-based reports. Explore salary trends and burnout data on our Market Pulse dashboard.

Frequently Asked Questions

How much do nurse practitioners earn in South Dakota?

Listed nurse practitioners in South Dakota on WeekdayDoc pay roughly $93K to $157K per year, with a median near $108K. Actual pay varies by specialty, setting, experience, and shift type — every listing shows its salary upfront.

Are there remote or hybrid nurse practitioners jobs available?

Some nurse practitioners roles offer remote or hybrid flexibility. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.

Which nurse practitioners jobs have the best work-life balance?

Every nurse practitioner role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 10% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.

Who is hiring nurse practitioners in South Dakota right now?

Employers currently hiring for nurse practitioner roles include Avera Health, Sanford Health, Commonwealth Medical Services, ENCOMPASS WELLNESS P, and others. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.

How many nurse practitioner jobs in south dakota are available, and how often are they updated?

There are currently 47+ nurse practitioners positions in South Dakota listed, with new roles added daily as employers post them. Create a free account to compare salaries and work-life-balance scores side by side, then apply directly.

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