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Mayo Clinic
Rochester, Minnesota

Nurse Practitioner or Physician Assistant - Medical Oncology Acute Cancer Care Clinic

Physician AssistantNo callFull-Time

Listed compensation

$120k-$167k

The week · per this posting · weekdays assumed

Ask the employer about the work setting, weekend coverage, nights and shift pattern and time off.

Posted 1h ago · Verified live

Job Description

The Nurse Practitioner (NP) or Physician Assistant (PA) in this position will play an integral role across our adult Medical Oncology and Hematology practice, caring for patients with early and advanced solid tumor and hematologic malignancies who require acute evaluation and management. The NP PA will address a broad range of needs, including symptom management, oncologic emergencies, and treatment-related adverse events such as immunotherapy-related toxicities.

This position is divided into four primary areas: three Acute Care Clinics (coverage for the Cancer Treatment Unit, REACH intervention rooms, outpatient acute care visits), and the Immunotherapy (ICI) Toxicity Clinic. Providers work closely with each patient's primary oncology and hematology teams to ensure timely, coordinated care across the continuum.

The Acute Cancer Care Clinic provides a critical role in decreasing emergency department visits by facilitating direct admissions and managing patients, when possible, in an outpatient setting with close follow up.

In addition, this role helps support shortened hospital length of stays by providing important follow up care for hospitalized cancer patients. This role supports our remote management nursing teams for cancer patients with neutropenic fevers and respiratory illness.

There are opportunities to help expand and innovate remote patient monitoring programs. This role provides triage support for acutely ill patients in the cancer treatment unit and for nursing managing patient calls.

The REACH intervention space will be a new clinic space that allows for IV interventions on the oncology floor (fluids, electrolytes, etc.).

In the Cancer Infusion Therapy Center, the provider plays a key role in the assessment and management of patients receiving systemic cancer therapy.

Responsibilities include responding to infusion reactions, evaluating acute cancer-related concerns that arise during treatment visits, coordinating urgent diagnostic workups and interventions, and collaborating closely with infusion nursing staff, pharmacists, and the primary oncology team to ensure safe, timely, and patient-centered care

The ICI toxicity clinic sees patients with toxicities that range from mild to emergent concerns. As part of the ICI toxicity clinic coverage, an individual will see patients in the outpatient setting to manage ICI toxicities.

This can be a one-time visit or many weeks to months of follow-up, depending on the individual patient’s needs.

Additionally, when covering the ICI toxicity clinic, an individual will cover the ICI service pager to provide collaborative support for outpatient and inpatient colleagues with questions regarding ICI toxicities. This is a growing practice, and we anticipate continued evolution of the role and responsibilities.

The individual(s) working in this position will rotate coverage of the Acute and ICI toxicity clinics. Pager coverage for ICI and Acute clinics will be held by different NP PAs working that day. The goal is to have 4 NP PAs working every day to cover these clinics.

This is an ideal role for an NP or PA to work autonomously, with collaborative support as needed. This role requires collaboration with the patient's primary cancer care team and a broad range of multidisciplinary partners, including Infectious Diseases, Gastroenterology, Interventional Radiology, Pulmonary Medicine, Palliative Care, Emergency Medicine, and other hospital-based services.

This is a fast-paced and dynamic practice that requires strong communication, critical thinking, adaptability, and time management skills. Successful candidates will have a solid foundation in internal medicine, a passion for oncology care, and an interest in continuous learning, quality improvement, and program development.

This is a rapidly evolving practice with continued growth in acute oncology and immunotherapy toxicity management. Current initiatives include the development of enhanced observation capabilities to support real-time interventions, improve patient access, and prevent escalation of care when possible.

Providers in this role will have opportunities to partner with clinical and operational leadership to shape workflows, expand services, and advance patient-centered oncology care across Mayo Clinic's three shields.

Qualifications

Masters-prepared graduate of an accredited school of nursing and Nurse Practitioner program. Current Minnesota RN license and certification (or eligible to be certified) as a FNP, ANP, or ACNP (certification must be obtained within 6 months of employment date). Must be eligible for DEA registration and billing privileges.

or

Graduate of accredited Physician Assistant program with current PA certification by NCCPA and registration as a PA by the Minnesota Board of Medical Practice (or eligible). Must be eligible for DEA registration and billing privileges.

External and Internal candidates for this position are asked to attach 2-3 letters of reference to their online application to be considered for this position.

New graduates please upload 3 letters of reference from preceptors that can attest to your clinical abilities.

Mayo Clinic employees applying for this position are asked to attach 3 most recent performance evaluations to online application to be considered for this position.

Key Responsibilities

Provide acute evaluation and management for adult oncology and hematology patients, including symptom management, oncologic emergencies, treatment-related adverse events, and immunotherapy toxicities across outpatient clinics and infusion settings. Coordinate care with primary oncology teams and multidisciplinary partners, support triage and remote monitoring, and help develop services that improve access and prevent escalation of care.

Qualifications

Education
Master's degree (postgraduate degree)
Experience
5+ years of experience

Certifications

DEA License

Key Skills

Acute Oncology CareOncologic Emergency ManagementClinical AssessmentCare CoordinationMultidisciplinary Collaboration

Work-Life Balance Analysis

WeekdayDoc's proprietary algorithm rates Nurse Practitioner or Physician Assistant - Medical Oncology Acute Cancer Care Clinic at Mayo Clinic a 6.4 out of 10 for work-life balance — classified as good. This places the position in the top 25% in Oncology (PA) — ranked against 89 active Oncology (PA) listings on WeekdayDoc. Contributing factors include no on-call duties.

Oncology — Physician Assistant Career Context

Mayo Clinic ranks #7 of 16 employers hiring Physician Assistant on WeekdayDoc by average advertised pay.

Of the 50 active Oncology listings this role was benchmarked against, 14% are remote, 60% have no call, 68% require no weekends.

Oncology by the numbers
MeasureThis jobMarket
Work-life score6.4 / 10 · top 25% in oncology (pa)ranked against 89 Oncology (PA) listingslisting-based score, 0–10
Listed pay$120k–$167kOncology median $126k (middle half $110k–$155k)42 comparable listings, Nov 2026
Cost-of-living adjusted pay~$146k in purchasing powerMinnesota index 98.6 (US = 100)BEA Regional Price Parities (2024)
Work settingon-sitepeers: 14% remote · 60% no call · 68% no weekends50 benchmarked listings
Sign-on & loan repaymentnot statedMinnesota Physician Assistant listings: 8% state a sign-on bonus · 21% offer loan repayment118 active listings, Nov 2026
Oncology hiring demandnot ranked this monthpostings stay open a median 52 daysWeekdayDoc Hiring Index, October 2026 · 44 postings, 30 closed
New Oncology listings432 in the last 30 days385 the 30 days before (+12%)U.S., first seen on WeekdayDoc, Nov 2026
Oncology pay trend+19.8% vs prior quarter—through Oct 2026
Mayo Clinic#7 of 16 for payTop Employers work-life index
Sources: WeekdayDoc live listing index (89 Oncology (PA) listings), Top Employers work-life index, BEA Regional Price Parities (2024), WeekdayDoc Hiring Index; as of Nov 2026. Same values as the Weekday Verdict and Market Insights on this page.

Top Physician Assistant Jobs

39 matches · ranked by pay

Salary Distribution

39 jobs · 26 employers
14
<$145k
12
$145k-170k
8
$170k-195k
2
$195k-220k
3
$220k+

Annual compensation range

Benefits & Perks

38 jobs · 26 employers
401k / retirement match
87%
CME allowance
61%
Sign-on bonus
53%
Loan repayment
21%
Relocation assistance
11%

Share of similar jobs offering each benefit

#1

Clinical Director, Physician Assistant

Pine Park Health · San Francisco, California

$200k-$240k
#2

Outpatient Advanced Practice Provider (APP), Nurse Practitioner or Physician Assistant/Associates

Oregon Health & Science University · Portland, Oregon

$172k-$229k
#3

Physician Assistant

$150k-$225k
#4

Clinic Director - Physician Assistant (PA-C) or Nurse Practitioner (NP)

$210k
+ 37 more · ranked by pay

Work-life snapshot

median 3.9this job 6.4
Better work-life than 80% of Oncology (PA) listings

Listing-based score, 0–10, across 89 comparable listings. Shaded area = the share scoring below this one.

  • No call

Living in Rochester

Typical 3-bedroom home value
$305k≈ 2.5× annual pay
Typical market rent
$1,602/mo≈ 16% of gross pay
Residents’ average commute
17 min
Metro price indexU.S. average = 100
90.8
State income tax
Up to 9.8%
Sources & methodology

Sources: Zillow home values (Sep 2026), Zillow market rents (Sep 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · Rochester, MN metro prices. Housing figures are city-level.

Ratios use this listing’s gross annual pay. Not a cost-of-living guarantee.