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University of Chicago
Chicago, Illinois

Clinical Research Nurse

Registered NurseFull-Time

Listed compensation

$70k-$100k

The week · per this posting · weekdays assumed

Ask the employer about the work setting, call expectations, weekend coverage and time off.

Posted 1h ago · Verified live

Job Description

Department: BSD CRC - Nursing

About the Department

The University of Chicago (UC) Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science.

Its ultimate goals are to train scientists and health care providers at UC and in our community to determine the molecular, genetic, pathophysiologic, and social determinants of disease and disease predisposition in individuals; to test interventions directed toward those mechanisms; and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our community’s needs and values.

Over its thirteen years, the ITM has capitalized on the outstanding intellectual and physical resources throughout the University and at ITM affiliate Institutions, Argonne National Laboratory, NorthShore University HealthSystem, Illinois Institute of Technology, and Access Community Health Network, and on substantial institutional and CTSA financial investments, to build the infrastructure for a transformative, energized, and self-improving home for clinical and translational research, ensuring the continued progress of clinical and translational science at the University of Chicago, its affiliates, on the South Side of Chicago, and beyond.

Job Summary

Reporting directly to the Clinical Research Center Nurse Manager, the Clinical Research Center (CRC) Nurse supports a wide range of clinical research projects/studies involving various study designs and participant procedures. These include multi‐center cooperative group and intergroup trials, multi‐institutional pharmaceutical trials, single and multi‐center investigator-initiated trials, as well as observational, registry and phenotypic studies conducted within the CRC.

This at-will position is wholly or partially funded by contractual grant funding which is renewed under provisions set by the grantor of the contract.

Responsibilities

Works with research participants across the lifespan, including pediatric, adult, and geriatric populations.

Provides direct patient care: Performs nursing assessments, conducts protocol specified procedures, administers study medications/investigational products, and monitors patient safety during visits.

Collects and manages data: Records clinical data, maintains case report forms, and supports data integrity for audits and monitoring visits.

Collaborates with multidisciplinary teams including physicians, coordinators, and lab staff to support study progress.

Educates participants and families: Explains study procedures and provide ongoing support across study timeline.

Adheres to ICH-GCP guidelines, professional nursing practice standards, patient-centered care principles and evidence based best practices in all interactions with research participants.

Reports adverse drug reactions and other safety concerns to the Principal Investigator and study team.

Interprets information from caregivers, nurses, or physicians about patient condition, treatment plans, or appropriate activities.

Has a solid understanding of the information and techniques needed to diagnose and treat human injuries, diseases, and deformities. This includes symptoms, treatment alternatives, drug properties and interactions, and preventive health-care measures.

Performs other related work as needed.

Minimum Qualifications

Education

Minimum requirements include a college or university degree in related field.

Work Experience

Minimum requirements include knowledge and skills developed through 2-5 years of work experience in a related job discipline.

Preferred Qualifications

Education

Bachelor of Science Degree in Nursing.

Experience

Two years of experience as a nurse in clinical research coordination/management.

Preferred Competencies

  • Fundamental working knowledge of clinical research.
  • Knowledge of patient care fundamentals, including aseptic principles and techniques.
  • Ability to provide direct patient care in a professional and respectful manner.
  • Excellent verbal and written communication.
  • Ability to read documents or instruments.
  • Ability to perform multiple concurrent tasks with occasional interruptions.
  • Ability to exercise discretion and confidentiality while handling sensitive situations.
  • Ability to solve problems by applying math or reasoning principles.
  • Ability to adapt to changing working situations and work assignments.
  • Strong phlebotomy and venous access (IV) skills.
  • Working Conditions

This role works in a fast-paced clinical setting.

Application Documents

Resume/CV (required)

Cover Letter (required)

The University of Chicago uses AI-assisted tools to streamline and augment some recruitment processes; however, AI is not used to make hiring decisions.

When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.

Job Family

Healthcare & Medical Services

Role Impact

Individual Contributor

Scheduled Weekly Hours

40

Drug Test Required

Yes

Health Screen Required

Yes

Motor Vehicle Record Inquiry Required

No

Pay Rate Type

Salary

FLSA Status: Exempt

Pay Range

$70,000.00 - $100,000.00

The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting.

Benefits Eligible

Yes

The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook.

Posting Statement

The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.

All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.

The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information.

The Report can be accessed online at: securityreport.uchicago.edu. Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.

Requirements

Candidates must hold a college or university degree in a related field and possess 2-5 years of relevant work experience. A Bachelor of Science in Nursing and prior experience in clinical research coordination are preferred.

Qualifications

Experience
2+ years of experience

Key Skills

Nursing assessmentData managementPatient safety monitoringClinical documentationMultidisciplinary collaborationMedication administrationProtocol compliancePatient educationAseptic techniques

Ambulatory Care Nursing — Registered Nurse Career Context

Of the 50 active Ambulatory Care Nursing listings this role was benchmarked against, 30% are remote, 58% have no call, 72% require no weekends.

The cost-of-living index for Illinois is 100.0 (US average = 100; BEA Regional Price Parities (2024)), so the posted ~$85k midpoint carries the purchasing power of roughly $85k in an average-cost state. 62.6% of Illinois clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

Ambulatory Care Nursing pay on WeekdayDoc is down 1.1% vs. the prior quarter (through Sep 2026).

Top Registered Nurse Jobs

25 matches · ranked by pay

Salary Distribution25 jobs · 22 employers

7
<$95k
5
$95k-115k
7
$115k-135k
5
$135k-155k
1
$165k

Annual compensation range

Benefits & Perks19 jobs

401k / retirement match
89% this job
Loan repayment
21%
PSLF eligible
21%
CME allowance
16%
Sign-on bonus
5%

Share of similar jobs offering each benefit

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#2

Registered Nurse (RN) Patient Care Navigator - Transplant Infectious Diseases

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#3

Asst. Director of Nursing - Ambulatory Care - Newkirk Avenue

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#4

Director of Nursing

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+ 23 more · ranked by pay

Work-life snapshot

median 5.1this job 3.0
Better work-life than 20% of Ambulatory Care Nursing (RN) listings

Listing-based score, 0–10, across 383 comparable listings. Shaded area = the share scoring below this one.

Living in Chicago

Typical 3-bedroom home value
$356k≈ 5.1× annual pay
Typical market rent
$2,342/mo≈ 40% of gross pay
Residents’ average commute
33 min
State income tax
Up to 5%
Sources & methodology

Sources: Zillow home values (Aug 2026), Zillow market rents (Aug 2026), U.S. Census ACS 2024 five-year.

Ratios use this listing’s gross annual pay. Not a cost-of-living guarantee.

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About University of Chicago

Research Services
Chicago, IL
51-200 employees

Benefits & Perks

Health Insurance
Retirement Plan
Paid Time Off