Nurse Practitioner Jobs in South Carolina
Across 302 live Nurse Practitioner listings in South Carolina, median advertised pay is $164K (75th percentile $190K), based on the 78 that state a salary; South Carolina ranks 36th of 51 states by median advertised pay; the employers with the most openings are MUSC (35), Prisma Health (35), Prisma Health Urgent Care (20).
302+ positions available
Figures are computed from live listings and reviewed by WeekdayDoc’s physician-led editorial team; data as of October 16, 2026. Posted ranges, not accepted offers. How we compute this
302+ Nurse Practitioner Jobs in South Carolina Available Now
These 78 roles pay ~$164k median with 6.5/10 median work-life balance — use these as your benchmarks.
Nurse Practitioner or Physician Assistant - Hematology Oncology
Locum NP (Nurse Practitioner), PA (Physician's Assistant) Trauma Surgery
Rinvio RecruitmentMyrtle Beach, SC
Emergency Medicine APP (NP/ PA) – Murrells Inlet and Georgetown, SC
Nurse Practitioner - Orangeburg, SC
Marathon HealthEmployer score · SilverOrangeburg, SC
Nurse Practitioner or Physician Assistant - Fri/Sat/Sun or Sat/Sun/Mon
Nurse Practitioner - Industry - Occupational Health - Florence
Nurse Practitioner - McLeod Women's Care - Clarendon
Nurse Practitioner - McLeod Digestive Health Center Florence
Nurse Practitioner - Psychiatric - $10k sign-on bonus
Nurse Practitioner - Psychiatric - $10k sign-on bonus
Nurse Practitioner or Physician Assistant- Primary Care - Optum/Colonial Healthcare
UnitedHealth GroupEmployer score · SilverColumbia, SC
Aesthetic Nurse Practitioner
AURĀE Modern Medical + SMount Pleasant, SC
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How South Carolina Compares for Nurse Practitioner Pay
South Carolina against neighboring states and the top payers, from our own nurse practitioner postings over the last 12 months — not a salary survey.
Nurse Practitioner roles in South Carolina advertise $3k below the $135k median across the 51 states we can measure, where California leads at $163k.
| State | Median pay | vs SC | WLB | Listings |
|---|---|---|---|---|
| South Carolina (this page) | $132k | — | 5.2/10 | 900 |
| California#1 | $163k | +$31k | 5.3/10 | 3043 |
| Washington#2 | $153k | +$21k | 5.5/10 | 882 |
| Oregon#3 | $152k | +$20k | 6.0/10 | 650 |
| Alaska#4 | $152k | +$20k | 5.3/10 | 77 |
| Rhode Island#5 | $151k | +$20k | 5.6/10 | 178 |
| Georgiaborders | $133k | +$2k | 5.1/10 | 1214 |
| North Carolinaborders | $130k | −$2k | 5.4/10 | 1161 |
“borders” = shares a border with South Carolina; “#n” = national pay rank among the 51 measured states.
Nurse Practitioner Jobs in South Carolina: Market Overview & Work-Life Balance
Listing snapshot: this overview summarizes the jobs loaded on this page. Market comparisons use the separate scope and time period labeled in their section.
South Carolina offers a competitive market for healthcare professionals seeking nurse practitioner jobs in south carolina. With 302+ open positions, clinicians have strong options for career growth and work-life balance.
Every listing is evaluated using WeekdayDoc's proprietary work-life balance scoring system. Nurse Practitioner Jobs in South Carolina on this page have an average score of 4.5/10. This data helps clinicians quickly identify positions that match their lifestyle priorities without reading through hundreds of job descriptions.
Leading employers currently hiring for nurse practitioner jobs in south carolina include Curana Health, McLeod Health, MUSC, Pruitt Health, and more. Positions span nurse practitioner jobs south carolina. New jobs are added daily as healthcare organizations expand their teams.
Among the top-rated employers hiring for nurse practitioner jobs in south carolina, BetterHelp (score: 95.9/100), Talkiatry (score: 95.0/100), Hiaah (score: 94.5/100) have earned WeekdayDoc's Top Employer designation based on our proprietary ranking system. This ranking evaluates burnout scores (40%), salary competitiveness (30%), and work-life balance features like no-call and remote options (30%). See the full rankings on our Top Employers page.
According to WeekdayDoc's Market Pulse — which tracks real-time compensation data from thousands of active job postings — the current median salary is $105K, trending up 3.4% over the past quarter. This data is derived from 31,769+ job postings analyzed over the past 12 months — updated daily, unlike annual survey-based reports. Explore salary trends and burnout data on our Market Pulse dashboard.
A few things worth knowing
About Nurse Practitioner jobs in South Carolina.
How much do nurse practitioners earn in South Carolina?
A reliable salary estimate is unavailable for this sample of nurse practitioners. Compensation varies by role, specialty, location, and schedule. Compare employer-posted pay where disclosed, including its currency and pay period; missing pay is not estimated.
Are there remote or hybrid nurse practitioners jobs available?
Some nurse practitioners roles offer remote or hybrid flexibility. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.
Which nurse practitioners jobs have the best work-life balance?
Every nurse practitioner role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. You can sort by work-life-balance score to surface the lowest-burnout roles first.
Who is hiring nurse practitioners in South Carolina right now?
Employers currently hiring for nurse practitioner roles include Curana Health, McLeod Health, MUSC, Pruitt Health, and others. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.
How many nurse practitioner jobs in south carolina are available, and how often are they updated?
There are currently 302 nurse practitioners positions in South Carolina listed, with new roles added as employers post them. Job descriptions are public. Verified sign-in with Google or email gives free access to regular Apply, full search, and standard Market Insights. Saved jobs, My Search, and the dashboard also require verified sign-in. Eligible featured employer listings allow Apply without signup or email. Basic calculators are public and free; optional AI contract analysis, RVU Billing Optimizer, and Schedule Optimizer reports remain paid.
Employers hiring now
Organizations with the most openings in Nurse Practitioner Jobs in South Carolina
MUSC35 open roles here · WLB 55/100
Prisma Health35 open roles here · WLB 51/100
Prisma Health Urgent Care20 open roles here · WLB 76/100
WellStreet Urgent Care19 open roles here · WLB 78/100
Lexington Medical Center16 open roles here · WLB 48/100
Matrix Medical Network16 open roles here · WLB 74/100Curana Health14 open roles here · WLB 64/100
Pruitt Health12 open roles here · WLB 72/100