Senior Medical Director, Oncology Clinical Development - Lung

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most — advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.

The Senior Medical Director, Oncology Clinical Development - Lung is a senior physician leader within the clinical programme team, providing medical oversight, strategic clinical insight, and a patient-centred perspective across the design, conduct, and interpretation of clinical studies. This role ensures that medical considerations, patient safety, and clinical integrity are consistently applied across studies within a programme.

Operating within the clinical strategy defined by the Clinical Development Lead (CDL), the Senior Medical Director partners closely with the Senior Scientist and cross-functional teams to guide the integration of physician expertise into study execution and programme-level decision-making. The role serves as a senior member of the Clinical Matrix Team (CMT), contributing to complex clinical decisions, regulatory interactions, and external scientific engagement.

The Senior Medical Director provides oversight and guidance to Medical Directors within the programme, supporting consistency of clinical judgement, safety evaluation, and medical interpretation across studies.

PLEASE NOTE: This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK’s Switzerland (Zug), Poland (Warsaw), UK (Stevenage or London HQ) or US (PA or MA) sites.

In This Role You Will

Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation

Provide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standards

Interpret complex clinical and safety data, generating insights that inform programme-level decisions led by the CDL

Partner with the Senior Scientist and cross-functional teams to ensure medical considerations are integrated across study execution and programme delivery

Provide senior medical input into protocol development and study design, ensuring clinical relevance and patient-centred design within the clinical strategy defined by the CDL

Serve as a senior member of the CMT, influencing study-level and programme-level decision-making

Engage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums

Provide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capability

Detailed Responsibilities

Medical Monitoring and Safety Oversight consistency in approach, patient safety, and protocol adherence

Guide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit–risk evaluation across the programme

Participate in and contribute to safety review forums (e. g., SRT, IDMC), providing senior physician perspective on complex safety questions

Ensure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standards

Study Design and Execution

Provide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDL

Guide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or multi-study programmes

Support resolution of complex medical questions arising during study conduct, applying clinical judgement to inform programme-level decision-making

Ensure consistency of medical considerations across multiple studies within the programme

Data Interpretation and Scientific Contribution

Interpret complex clinical data across studies, integrating findings to inform programme-level insights on safety, efficacy, and patient impact

Contribute to programme-level data interpretation and support CDL-led benefit–risk assessment and clinical positioning

Guide development of scientific communications, including publications, congress materials, and clinical summaries

Maintain deep understanding of disease biology, evolving treatment paradigms, and competitive landscape to inform clinical interpretation and programme strategy

Regulatory and External Engagement

Contribute senior medical expertise to regulatory interactions and Health Authority discussions, including responses to complex clinical and safety queries

Represent the programme at advisory boards, steering committees, and external scientific forums, providing senior physician perspective on clinical data and programme direction

Engage with KEEs and scientific collaborators to support programme development, scientific exchange, and external credibility

Lead or contribute to the clinical and technical diligence assessment of business development opportunities

Cross-Functional Collaboration and Clinical Matrix Team

Serve as a senior member of the Clinical Matrix Team (CMT), influencing cross-functional alignment and programme-level decision-making

Contribute medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussions

Collaborate across functions to ensure alignment on safety, data interpretation, and clinical positioning across the programme

Lead or contribute to Oncology Clinical Development-wide initiatives and workstreams

People Leadership & Capability Development

Provide oversight, guidance, and mentorship to Medical Directors within the programme, supporting consistency and quality of medical input across studies

Support development of clinical capability within the medical team, including coaching on medical monitoring, data interpretation, and external engagement

Contribute to talent development, performance discussions, and capability building within Oncology Clinical Development

Basic Qualifications

Medical degree and completion of advanced specialty training, fellowship or country-equivalent higher-level qualification in oncology, haematology, or a related specialty

Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes

• Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies
• Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks

Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions

Preferred Qualifications

Strong scientific communication and stakeholder engagement skills, with the ability to influence internal and external audiences

• Deep experience in oncology clinical development across multiple studies or programmes, including Phase I–III
• Experience contributing to or leading aspects of regulatory interactions (e. g., IND, scientific advice, NDA/MAA)
• Demonstrated experience engaging with KEEs, advisory boards, and scientific communities in oncology
• Track record of scientific publications and congress presentations
• Deep understanding of oncology disease biology and the evolving treatment landscape across solid tumours and/or haematological malignancies
• Experience mentoring or providing oversight to other physicians within a clinical development organisation
• Experience contributing to clinical and technical diligence for business development opportunities

Skills

Clinical Data Interpretation, Clinical Pharmacology, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction

• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,250 to $473,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Polish Salary Range / Polski przedział wynagrodzenia: PLN 593,250 to PLN 988,750The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role