Physician Assistant Jobs in South Carolina
Across 104 live Physician Assistant listings in South Carolina, median advertised pay is $150K (75th percentile $160K), based on the 26 that state a salary; South Carolina ranks 39th of 51 states by median advertised pay; the employers with the most openings are Prisma Health (18), Prisma Health Urgent Care (15), Curana Health (12).
104+ positions available
Figures are computed from live listings and reviewed by WeekdayDoc’s physician-led editorial team; data as of October 15, 2026. Posted ranges, not accepted offers. How we compute this
104+ Physician Assistant Jobs in South Carolina Available Now
These 26 roles pay ~$150k median with 4.8/10 median work-life balance — use these as your benchmarks.
Nurse Practitioner / Physician Assistant - Employer Health Services - Greenville
Nurse Practitioner or Physician Assistant
Prisma Health Urgent CarePowdersville, SC
Nurse Practitioner or Physician Assistant
Prisma Health Urgent CareEasley, SC
Nurse Practitioner or Physician Assistant | Up to $5k Sign On Bonus
Prisma Health Urgent CareBoiling Springs, SC
Nurse Practitioner or Physician Assistant | Part Time
Prisma Health Urgent CareClemson, SC
Nurse Practitioner or Physician Assistant - Up to $5k Sign On Bonus
Prisma Health Urgent CareLaurens, SC
Nurse Practitioner or Physician Assistant - Anderson, SC
University Hospitals Urgent CareAnderson, SC
Nurse Practitioner or Physician Assistant
Prisma Health Urgent CareGreenville, SC
Nurse Practitioner or Physician Assistant |Clemson
Prisma Health Urgent CareClemson, SC
Nurse Practitioner or Physician Assistant |Travelers Rest
Prisma Health Urgent CareTravelers Rest, SC
Nurse Practitioner or Physician Assistant | Powdersville | Part Time
Prisma Health Urgent CarePowdersville, SC
Nurse Practitioner or Physician Assistant | Seneca
Prisma Health Urgent CareSeneca, SC
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How South Carolina Compares for Physician Assistant Pay
South Carolina against neighboring states and the top payers, from our own physician assistant postings over the last 12 months — not a salary survey.
Physician Assistant roles in South Carolina advertise $7k below the $135k median across the 51 states we can measure, where Alaska leads at $168k.
| State | Median pay | vs SC | WLB | Listings |
|---|---|---|---|---|
| South Carolina (this page) | $128k | — | 5.0/10 | 507 |
| Alaska#1 | $168k | +$40k | 5.2/10 | 37 |
| California#2 | $163k | +$35k | 4.9/10 | 1806 |
| Washington#3 | $155k | +$27k | 5.2/10 | 547 |
| Oregon#4 | $154k | +$26k | 5.8/10 | 355 |
| Hawaii#5 | $151k | +$23k | 4.2/10 | 28 |
| Georgiaborders | $128k | −$0k | 4.7/10 | 566 |
| North Carolinaborders | $127k | −$1k | 5.2/10 | 658 |
“borders” = shares a border with South Carolina; “#n” = national pay rank among the 51 measured states.
Physician Assistant Jobs in South Carolina: Market Overview & Work-Life Balance
Listing snapshot: this overview summarizes the jobs loaded on this page. Market comparisons use the separate scope and time period labeled in their section.
South Carolina offers a competitive market for healthcare professionals seeking physician assistant jobs in south carolina. With 104+ open positions, clinicians have strong options for career growth and work-life balance.
Every listing is evaluated using WeekdayDoc's proprietary work-life balance scoring system. Physician Assistant Jobs in South Carolina on this page have an average score of 6.9/10, with 10% with no on-call requirements, 20% with no weekends. This data helps clinicians quickly identify positions that match their lifestyle priorities without reading through hundreds of job descriptions.
Leading employers currently hiring for physician assistant jobs in south carolina include Prisma Health Urgent Care, Carolina Health Specialists, Prisma Health, University Hospitals Urgent Care, and more. Positions span physician assistant jobs south carolina. New jobs are added daily as healthcare organizations expand their teams.
Among the top-rated employers hiring for physician assistant jobs in south carolina, BetterHelp (score: 95.9/100), Talkiatry (score: 95.0/100), Hiaah (score: 94.5/100) have earned WeekdayDoc's Top Employer designation based on our proprietary ranking system. This ranking evaluates burnout scores (40%), salary competitiveness (30%), and work-life balance features like no-call and remote options (30%). See the full rankings on our Top Employers page.
According to WeekdayDoc's Market Pulse — which tracks real-time compensation data from thousands of active job postings — the current median salary is $105K, trending up 3.4% over the past quarter. This data is derived from 31,769+ job postings analyzed over the past 12 months — updated daily, unlike annual survey-based reports. Explore salary trends and burnout data on our Market Pulse dashboard.
A few things worth knowing
About PA jobs in South Carolina.
How much do physician assistants earn in South Carolina?
A reliable salary estimate is unavailable for this sample of physician assistants. Compensation varies by role, specialty, location, and schedule. Compare employer-posted pay where disclosed, including its currency and pay period; missing pay is not estimated.
Are there remote or hybrid physician assistants jobs available?
Some physician assistants roles offer remote or hybrid flexibility. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.
Which physician assistants jobs have the best work-life balance?
Every physician assistant role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 10% with no on-call and 20% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.
Who is hiring physician assistants in South Carolina right now?
Employers currently hiring for physician assistant roles include Prisma Health Urgent Care, Carolina Health Specialists, Prisma Health, University Hospitals Urgent Care, and others. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.
How many physician assistant jobs in south carolina are available, and how often are they updated?
There are currently 104 physician assistants positions in South Carolina listed, with new roles added as employers post them. Job descriptions are public. Verified sign-in with Google or email gives free access to regular Apply, full search, and standard Market Insights. Saved jobs, My Search, and the dashboard also require verified sign-in. Eligible featured employer listings allow Apply without signup or email. Basic calculators are public and free; optional AI contract analysis, RVU Billing Optimizer, and Schedule Optimizer reports remain paid.
Employers hiring now
Organizations with the most openings in Physician Assistant Jobs in South Carolina
Prisma Health18 open roles here · WLB 51/100
- Prisma Health Urgent Care15 open roles here · WLB 76/100
Curana Health12 open roles here · WLB 64/100
Self Regional Healthcare9 open roles here · WLB 66/100
McLeod Health7 open roles here · WLB 75/100UnitedHealth Group5 open roles here · WLB 70/100
Lexington Medical Center4 open roles here · WLB 48/100MUSC4 open roles here · WLB 55/100