ICON plc logo
ICON plc
San Antonio, Texas

Clinical Research Nurse I

Registered NurseNo weekendsNo nightsPer Diem

Compensation

Pay not listed

The week · per this posting · Monday – FridayWeekdays only

Ask the employer about the pay range, call expectations and time off.

Posted 1h ago · Verified live

Job Description

Clinical Research Nurse I- San Antonio TX- ICON PRN M-F Day Shift

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

Title: Clinical Research Nurse I

Location: 100% on site- San Antonio TX 78232

Job Type: PRN/ As Needed

Shift/schedule: M-F 6 AM-230 PM

What You Will Do

Your role will involve delivering clinical research operations work to a high standard, working closely with your team and stakeholders. You will support the execution of clinical trials, ensuring adherence to protocol requirements, and provide compassionate patient care throughout the research process.

Key Responsibilities Include

Assisting in the planning, implementation, and coordination of clinical research activities in accordance with study protocols, regulatory guidelines, and standard operating procedures (SOPs).

Conducting patient assessments, administering study treatments, and performing clinical procedures as required by the research protocol, while ensuring patient safety and compliance with ethical standards.

Collecting, recording, and maintaining accurate and complete data documentation, including medical histories, vital signs, adverse events, and laboratory results, in electronic case report forms (eCRFs) and study databases.

Collaborating with multidisciplinary teams, including investigators, study coordinators, and regulatory staff, to ensure efficient study conduct, participant recruitment, and retention throughout the duration of the trial.

Providing education and counseling to study participants and their families regarding study procedures, treatment regimens, and informed consent, while addressing any questions or concerns that may arise during the course of the study.

Your Profile

Required Qualifications and Experience

Bachelor's degree in Nursing (BSN) from an accredited institution, with current licensure as a Registered Nurse (RN) in the applicable jurisdiction.

Minimum of 1-2 years of clinical nursing experience, preferably in a research or academic healthcare setting, with exposure to clinical trial operations and Good Clinical Practice (GCP) guidelines.

Strong clinical assessment and critical thinking skills, with the ability to recognize and respond to changes in patient status and communicate effectively with healthcare professionals and study investigators.

Knowledge of regulatory requirements governing clinical research, including the International Council for Harmonisation (ICH) guidelines and local regulatory requirements, with a commitment to upholding ethical standards and patient confidentiality.

Proficiency in electronic medical record (EMR) systems, clinical documentation, and data entry, with a high level of attention to detail and accuracy in recording patient information and study data.

Excellent interpersonal and organizational skills, with the ability to work independently and collaboratively in a fast-paced, multidisciplinary environment, while prioritizing competing demands and meeting project deadlines.

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits May Include

  • Competitive base salary and performance related incentives
  • Health and wellbeing programmes including medical, dental, and vision coverage where applicable
  • Retirement and pension plans
  • Life assurance and disability coverage
  • Employee assistance programmes and wellbeing resources
  • Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

Visit our careers site to read more about the benefits ICON offers.

Inclusion and Accessibility

ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.

If you require reasonable accommodations during the recruitment process, please let us know or submit a request here.

Are you a current ICON Employee? Please click here to apply

Key Responsibilities

The Clinical Research Nurse will support the execution of clinical trials by conducting patient assessments, administering treatments, and performing clinical procedures according to study protocols. They are also responsible for maintaining accurate data documentation and collaborating with multidisciplinary teams to ensure participant safety and regulatory compliance.

Requirements

Candidates must hold a Bachelor's degree in Nursing (BSN) and a current Registered Nurse (RN) license. A minimum of 1-2 years of clinical nursing experience, preferably in research, along with knowledge of Good Clinical Practice (GCP) guidelines is required.

Qualifications

Education
Bachelor degree

Key Skills

Patient assessmentElectronic medical recordsStudy coordinationMedical history documentation

Ambulatory Care Nursing — Registered Nurse Career Context

Of the 50 active Ambulatory Care Nursing listings this role was benchmarked against, 30% are remote, 38% have no call, 78% require no weekends.

The cost-of-living index for Texas is 97.1 (US average = 100; BEA Regional Price Parities (2024)). 57.7% of Texas clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

How many Ambulatory Care Nursing jobs are remote?
MeasureThis jobMarket
Work-life score6.4 / 10 · top 25% in ambulatory care nursing (rn)ranked against 374 Ambulatory Care Nursing (RN) listingslisting-based score, 0–10
Listed paynot listedAmbulatory Care Nursing median $91k (middle half $85k–$108k)16 comparable listings, Nov 2026
Cost of livingTexas index 97.1US average = 100BEA Regional Price Parities (2024)
Ambulatory Care Nursing listings in Texas23 active387 nationallylive on WeekdayDoc, Nov 2026
Work settingon-sitepeers: 30% remote · 38% no call · 78% no weekends50 benchmarked listings
Sign-on & loan repaymentnot statedTexas Registered Nurse listings: 7% state a sign-on bonus (median $10k) · 4% offer loan repayment393 active listings, Nov 2026
New Ambulatory Care Nursing listings188 in the last 30 days66 the 30 days before (+185%)U.S., first seen on WeekdayDoc, Nov 2026
Ambulatory Care Nursing pay trend+12.0% vs prior quarter—through Oct 2026
Sources: WeekdayDoc live listing index (374 Ambulatory Care Nursing (RN) listings), BEA Regional Price Parities (2024); as of Nov 2026. Same values as the Weekday Verdict and Market Insights on this page.

Work-Life Balance Analysis

WeekdayDoc's proprietary algorithm rates Clinical Research Nurse I at ICON plc a 6.4 out of 10 for work-life balance — classified as good. This places the position in the top 25% in Ambulatory Care Nursing (RN) — ranked against 374 active Ambulatory Care Nursing (RN) listings on WeekdayDoc. Contributing factors include no weekend requirements, no night shifts.

Location & Logistics

Texas has no state income tax, which can significantly increase take-home pay compared to high-tax states.

Top contract/1099 Registered Nurse Jobs

44 matches · ranked by pay

Salary Distribution

44 jobs · 40 employers
15
<$100k
12
$100k-120k
12
$120k-140k
5
$140k-160k

Annual compensation range

Benefits & Perks

29 jobs
401k / retirement match
97% this job
Sign-on bonus
31%
CME allowance
21%
Loan repayment
14%
PSLF eligible
10%

Share of similar jobs offering each benefit

#1

Hospice Nurse Case Manager

By the Bay Health · Larkspur, Colorado

$65.7-$75.7/hr
#2

Registered Nurse - Case Manager w/sign-on bonus - 5403

Vantage Search Group · Twentynine Palms, California

$125k-$156k
#3

Assistant Director of Nursing - Mental Health 616

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#4

Triage Staff Nurse – Days – David H Koch Center GI, Hepatology, Irritable Bowel Disease Clinic - Weill Cornell Medical Center

$134k-$153k
+ 42 more · ranked by pay

Work-life snapshot

median 4.8this job 6.4
Better work-life than 80% of Ambulatory Care Nursing (RN) listings

Listing-based score, 0–10, across 374 comparable listings. Shaded area = the share scoring below this one.

  • No weekends
  • No nights
  • On-site
ICON plc logo

About ICON plc

Biotechnology Research
Dublin
10,000+ employees

Benefits & Perks

Competitive base salary
Performance incentives
Health insurance
Dental insurance
Vision insurance
Retirement plan
Life assurance
Disability coverage

Living in San Antonio

Typical 3-bedroom home value
$224k
Typical market rent
$1,381/mo
Residents’ average commute
25 min
Metro price indexU.S. average = 100
94.7
State income tax
None
Sources & methodology

Sources: Zillow home values (Sep 2026), Zillow market rents (Sep 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · San Antonio-New Braunfels, TX metro prices. Housing figures are city-level.

City-level figures. Not a cost-of-living guarantee.