Clinical Research Nurse I
Compensation
Pay not listed
The week · per this posting · Monday – FridayWeekdays only
Ask the employer about the pay range, call expectations and time off.
Job Description
Clinical Research Nurse I- San Antonio TX- ICON PRN M-F Day Shift
ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.
As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.
Title: Clinical Research Nurse I
Location: 100% on site- San Antonio TX 78232
Job Type: PRN/ As Needed
Shift/schedule: M-F 6 AM-230 PM
What You Will Do
Your role will involve delivering clinical research operations work to a high standard, working closely with your team and stakeholders. You will support the execution of clinical trials, ensuring adherence to protocol requirements, and provide compassionate patient care throughout the research process.
Key Responsibilities Include
Assisting in the planning, implementation, and coordination of clinical research activities in accordance with study protocols, regulatory guidelines, and standard operating procedures (SOPs).
Conducting patient assessments, administering study treatments, and performing clinical procedures as required by the research protocol, while ensuring patient safety and compliance with ethical standards.
Collecting, recording, and maintaining accurate and complete data documentation, including medical histories, vital signs, adverse events, and laboratory results, in electronic case report forms (eCRFs) and study databases.
Collaborating with multidisciplinary teams, including investigators, study coordinators, and regulatory staff, to ensure efficient study conduct, participant recruitment, and retention throughout the duration of the trial.
Providing education and counseling to study participants and their families regarding study procedures, treatment regimens, and informed consent, while addressing any questions or concerns that may arise during the course of the study.
Your Profile
Required Qualifications and Experience
Bachelor's degree in Nursing (BSN) from an accredited institution, with current licensure as a Registered Nurse (RN) in the applicable jurisdiction.
Minimum of 1-2 years of clinical nursing experience, preferably in a research or academic healthcare setting, with exposure to clinical trial operations and Good Clinical Practice (GCP) guidelines.
Strong clinical assessment and critical thinking skills, with the ability to recognize and respond to changes in patient status and communicate effectively with healthcare professionals and study investigators.
Knowledge of regulatory requirements governing clinical research, including the International Council for Harmonisation (ICH) guidelines and local regulatory requirements, with a commitment to upholding ethical standards and patient confidentiality.
Proficiency in electronic medical record (EMR) systems, clinical documentation, and data entry, with a high level of attention to detail and accuracy in recording patient information and study data.
Excellent interpersonal and organizational skills, with the ability to work independently and collaboratively in a fast-paced, multidisciplinary environment, while prioritizing competing demands and meeting project deadlines.
Employment with ICON is contingent upon having the legal right to work in the country where the role is based.
Rewards & Benefits
ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.
Benefits May Include
- Competitive base salary and performance related incentives
- Health and wellbeing programmes including medical, dental, and vision coverage where applicable
- Retirement and pension plans
- Life assurance and disability coverage
- Employee assistance programmes and wellbeing resources
- Learning and development opportunities through structured training and career pathways
Benefits may vary depending on role and location.
Visit our careers site to read more about the benefits ICON offers.
Inclusion and Accessibility
ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.
If you require reasonable accommodations during the recruitment process, please let us know or submit a request here.
Are you a current ICON Employee? Please click here to apply
Key Responsibilities
The Clinical Research Nurse will support the execution of clinical trials by conducting patient assessments, administering treatments, and performing clinical procedures according to study protocols. They are also responsible for maintaining accurate data documentation and collaborating with multidisciplinary teams to ensure participant safety and regulatory compliance.
Requirements
Candidates must hold a Bachelor's degree in Nursing (BSN) and a current Registered Nurse (RN) license. A minimum of 1-2 years of clinical nursing experience, preferably in research, along with knowledge of Good Clinical Practice (GCP) guidelines is required.
Qualifications
- Education
- Bachelor degree
Key Skills
Ambulatory Care Nursing — Registered Nurse Career Context
Of the 50 active Ambulatory Care Nursing listings this role was benchmarked against, 30% are remote, 38% have no call, 78% require no weekends.
The cost-of-living index for Texas is 97.1 (US average = 100; BEA Regional Price Parities (2024)). 57.7% of Texas clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).
| Measure | This job | Market |
|---|---|---|
| Work-life score | 6.4 / 10 · top 25% in ambulatory care nursing (rn) | ranked against 374 Ambulatory Care Nursing (RN) listingslisting-based score, 0–10 |
| Listed pay | not listed | Ambulatory Care Nursing median $91k (middle half $85k–$108k)16 comparable listings, Nov 2026 |
| Cost of living | Texas index 97.1 | US average = 100BEA Regional Price Parities (2024) |
| Ambulatory Care Nursing listings in Texas | 23 active | 387 nationallylive on WeekdayDoc, Nov 2026 |
| Work setting | on-site | peers: 30% remote · 38% no call · 78% no weekends50 benchmarked listings |
| Sign-on & loan repayment | not stated | Texas Registered Nurse listings: 7% state a sign-on bonus (median $10k) · 4% offer loan repayment393 active listings, Nov 2026 |
| New Ambulatory Care Nursing listings | 188 in the last 30 days | 66 the 30 days before (+185%)U.S., first seen on WeekdayDoc, Nov 2026 |
| Ambulatory Care Nursing pay trend | +12.0% vs prior quarter | —through Oct 2026 |
Work-Life Balance Analysis
WeekdayDoc's proprietary algorithm rates Clinical Research Nurse I at ICON plc a 6.4 out of 10 for work-life balance — classified as good. This places the position in the top 25% in Ambulatory Care Nursing (RN) — ranked against 374 active Ambulatory Care Nursing (RN) listings on WeekdayDoc. Contributing factors include no weekend requirements, no night shifts.
Location & Logistics
Texas has no state income tax, which can significantly increase take-home pay compared to high-tax states.
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