ICON plc logo
ICON plc
Lenexa, Kansas

Overnight Clinical Research Nurse (PRN)

Registered NursePer Diem

Compensation

Pay not listed

The week · per this posting

Ask the employer about the pay range, the work setting, call expectations and time off.

Posted 59m ago · Verified live

Job Description

Overnight Clinical Research Nurse I (Onsite) - Lenexa, KS

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

As a Clinical Research Nurse at ICON, you will play a critical role in the execution of clinical trials, providing direct patient care while ensuring the safety and well-being of research participants. This is an overnight position supporting clinical research studies involving investigational products and intensive patient monitoring.

What You Will Do

You will be responsible for delivering high-quality clinical research nursing care while supporting study protocols and participant safety during overnight operations.

Key Responsibilities Include

  • Administer investigational products according to study protocols and physician orders.
  • Monitor research participants during dosing procedures and throughout study participation.

Identify, assess, document, and report adverse events and other safety findings in accordance with study protocols and regulatory requirements.

Perform clinical assessments, vital signs collection, sample collection, and other protocol-required procedures.

Collaborate with physicians, research staff, and multidisciplinary teams to ensure protocol compliance and participant safety.

Accurately document study activities and maintain research records in accordance with Good Clinical Practice (GCP) guidelines.

  • Educate and support study participants throughout their clinical trial experience.
  • Support overnight clinical operations while maintaining a high standard of patient care and data quality.

Your Profile

You will bring relevant nursing and clinical research experience, along with the following qualifications and skills:

Required Qualifications and Experience

  • Associate's or Bachelor's degree in Nursing or a healthcare-related field.
  • Active Registered Nurse (RN) license in good standing.
  • Clinical research experience or experience working in a regulated healthcare environment preferred.
  • Knowledge of clinical trial processes, regulatory requirements, and Good Clinical Practice (GCP).
  • Experience administering medications and assessing patient responses.
  • Strong attention to detail and ability to recognize and respond to adverse events.
  • Excellent communication and documentation skills.
  • Ability to work independently and collaboratively in a fast-paced clinical research setting.
  • Ability and willingness to work overnight shifts.

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits May Include

  • Competitive base salary and performance related incentives
  • Health and wellbeing programmes including medical, dental, and vision coverage where applicable
  • Retirement and pension plans
  • Life assurance and disability coverage
  • Employee assistance programmes and wellbeing resources
  • Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

Visit our careers site to read more about the benefits ICON offers.

Inclusion and Accessibility

ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.

If you require reasonable accommodations during the recruitment process, please let us know or submit a request here.

Are you a current ICON Employee? Please click here to apply

Key Responsibilities

The Clinical Research Nurse will administer investigational products and monitor research participants during overnight study procedures. They are responsible for identifying and documenting adverse events while ensuring strict adherence to study protocols and safety standards.

Requirements

Candidates must hold an active Registered Nurse (RN) license and possess an Associate's or Bachelor's degree in Nursing or a related field. Experience in clinical research or a regulated healthcare environment is preferred, along with strong documentation and communication skills.

Qualifications

Education
Bachelor degree

Key Skills

Investigational product administrationAdverse event reportingPatient educationMedication administration

Ambulatory Care Nursing — Registered Nurse Career Context

Of the 50 active Ambulatory Care Nursing listings this role was benchmarked against, 38% are remote, 56% have no call, 66% require no weekends.

The cost-of-living index for Kansas is 90.1 (US average = 100; BEA Regional Price Parities (2024)). 61.0% of Kansas clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

How many Ambulatory Care Nursing jobs are remote?
MeasureThis jobMarket
Cost of livingKansas index 90.1US average = 100BEA Regional Price Parities (2024)
Ambulatory Care Nursing listings in Kansas7 active396 nationallylive on WeekdayDoc, Oct 2026
Work settingon-sitepeers: 38% remote · 56% no call · 66% no weekends50 benchmarked listings
Ambulatory Care Nursing pay trend−1.1% vs prior quarter—through Sep 2026
Sources: WeekdayDoc live listing index, BEA Regional Price Parities (2024); as of Oct 2026. Same values as the Weekday Verdict and Market Insights on this page.

Top contract/1099 Registered Nurse Jobs

40 matches · ranked by pay

Salary Distribution

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15
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4
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Annual compensation range

Benefits & Perks

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401k / retirement match
93% this job
Loan repayment
17%
CME allowance
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Sign-on bonus
10%
PSLF eligible
10%

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Work-life snapshot

median 5.1this job 3.0
Better work-life than 20% of Ambulatory Care Nursing (RN) listings

Listing-based score, 0–10, across 388 comparable listings. Shaded area = the share scoring below this one.

ICON plc logo

About ICON plc

Biotechnology Research
Dublin
10,000+ employees

Benefits & Perks

Competitive base salary
Health and wellbeing programmes
Retirement and pension plans
Life assurance and disability coverage
Employee assistance programmes
Learning and development opportunities

Living in Lenexa

Typical 3-bedroom home value
$372k
Typical market rent
$1,694/mo
Residents’ average commute
19 min
Metro price indexU.S. average = 100
92.5
State income tax
Up to 5.7%
Sources & methodology

Sources: Zillow home values (Aug 2026), Zillow market rents (Aug 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · Kansas City, MO-KS metro prices. Housing figures are city-level.

City-level figures. Not a cost-of-living guarantee.