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Registered Nurse Jobs in South Dakota

Across 30 live Registered Nurse listings in South Dakota, median advertised pay is $83K (75th percentile $101K), based on the 20 that state a salary; South Dakota ranks 44th of 51 states by median advertised pay; the employers with the most openings are Sanford Health (8), Monument Health (7), Avera Health (5).

30+ positions available

Figures are computed from live listings and reviewed by WeekdayDoc’s physician-led editorial team; data as of October 20, 2026. Posted ranges, not accepted offers. How we compute this

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30 jobs

These 20 roles pay ~$83k median with 6.4/10 median work-life balance — use these as your benchmarks.

Sanford Health logo

RN Triage - Registered Nurse - 32nd & Ellis Family Medicine Clinic - PT Days

Sanford HealthSioux Falls, SD

Registered Nurse
$29.5-$44.5 per hour
30+ days ago
No CallNo Nights
Sanford Health logo

Nurse Manager - RN - Gynecologic Oncology & Nurse Navigator

Sanford HealthSioux Falls, SD

Registered Nurse
Pay not disclosed
30+ days ago
No Nights
Avera Health logo

Registered Nurse (RN) | Oncology Outpatient Clinical Nurse Educator

Avera HealthAberdeen, SD

Registered Nurse
$29-$43.25 per hour
30+ days ago
No Nights
Dialysis Clinic logo

Dialysis Nurse Educator

Dialysis ClinicRapid City, SD

Registered Nurse
$39-$55 per hour
30+ days ago
Weekdays OnlyNo NightsNo Weekends
Avera Health logo

Registered Nurse (RN) Case Manager | Avera Health Plans Medical Management

Avera HealthSioux Falls, SD

Registered Nurse
$31-$46.25 per hour
No Nights
Sanford Health logo

RN Case Manager - Inpatient Days

Sanford HealthSioux Falls, SD

Registered Nurse
$36.5-$51 per hour
No Nights
Avera Health logo

Home Infusion RN Case Manager (RN)|MCK Home Infusion

Avera HealthSioux Falls, SD

Registered Nurse
$31-$46.25 per hour
Weekdays OnlyNo NightsNo Weekends
Sanford Health logo

RN Case Manager - Home Health & Hospice - PT

Sanford HealthChamberlain, SD

Registered Nurse
$34-$51 per hour
No Nights
Sanford Health logo

RN Case Manager - Hospice - Full Time Days

Sanford HealthSioux Falls, SD

Registered Nurse
$70,720 - $106,080/yr
No Nights
Sanford Health logo

RN Case Manager - Home Health - FT

Sanford HealthSioux Falls, SD

Registered Nurse
Salary Range: $36.50 - $51
No Nights

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Registered Nurse Pay in South Dakota: Live Market and State Comparison

Live registered nurse listings in South Dakota today, then South Dakota against neighboring states and the top payers over the last 12 months of our own postings — so every state is measured alike. Not a salary survey.

Live listings
30
Live median
$83k
75th $101k · n=20
12-mo median
$85k
Pay rank
#44 of 51
Work-life
4.5/10 · #20
12-mo postings
83

Registered Nurse roles in South Dakota advertise $7k below the $92k median across the 51 states we can measure, where Hawaii leads at $121k.

Registered Nurse median pay and work-life-balance score, South Dakota compared with neighboring states and the highest-paying states
StateMedian pay (12 mo)vs SDWLBPostings (12 mo)
South Dakota (this page)$85k—4.5/1083
Hawaii#1$121k+$37k4.4/1042
Wyomingborders$109k+$25k4.1/1025
Montanaborders$97k+$13k4.3/1069
Minnesotaborders$89k+$4k4.6/10558
Nebraskaborders$88k+$3k4.3/10128
North Dakotaborders$87k+$3k4.0/10100
Iowaborders$80k−$4k4.4/10357

“borders” = shares a border with South Dakota; “#n” = national pay rank among the 51 measured states. Live figures count the listings on WeekdayDoc today (updated Oct 20, 2026); 12-month figures include postings since closed, so states compare on the same basis.

Most openings on this page:
Sanford Health (8), Monument Health (7), Avera Health (5)
Top-rated employers hiring:
BetterHelp (gold, 96/100), Talkiatry (gold, 95/100), Hiaah (gold, 95/100) (Top Employers work-life index)

A few things worth knowing

About Registered Nurse jobs in South Dakota.

How much do registered nurses earn in South Dakota?

A reliable salary estimate is unavailable for this sample of registered nurses. Compensation varies by role, specialty, location, and schedule. Compare employer-posted pay where disclosed, including its currency and pay period; missing pay is not estimated.

Are there remote or hybrid registered nurse jobs available?

Some registered nurses roles offer remote or hybrid flexibility. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.

Which registered nurse jobs have the best work-life balance?

Every registered nurse role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 10% with no on-call and 20% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.

Who is hiring registered nurses in South Dakota right now?

Employers currently hiring for registered nurse roles include Sanford Health, Avera Health, Dialysis Clinic. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.

How many registered nurse jobs in South Dakota are available, and how often are they updated?

There are currently 30 registered nurses positions in South Dakota listed, with new roles added as employers post them. Job descriptions are public. Verified sign-in with Google or email gives free access to regular Apply, full search, and standard Market Insights. Saved jobs, My Search, and the dashboard also require verified sign-in. Eligible featured employer listings allow Apply without signup or email. Basic calculators are public and free; optional AI contract analysis, RVU Billing Optimizer, and Schedule Optimizer reports remain paid.