Nurse Practitioner Jobs in Missouri
Across 316 live Nurse Practitioner listings in Missouri, median advertised pay is $164K (75th percentile $175K), based on the 118 that state a salary; Missouri ranks 43rd of 51 states by median advertised pay; the employers with the most openings are CVS Health (40), Centurion Health (28), Washington University in St. Louis (25).
316+ positions available
Figures are computed from live listings and reviewed by WeekdayDoc’s physician-led editorial team; data as of October 16, 2026. Posted ranges, not accepted offers. How we compute this
316+ Nurse Practitioner Jobs in Missouri Available Now
These 118 roles pay ~$164k median with 6.6/10 median work-life balance — use these as your benchmarks.
Nurse Practitioner (NP/PA) - St. Joseph, Missouri (79890)
Centurion HealthSaint Joseph, MO
Nurse Practitioner for Family Medicine in Festus, MO
Full-time Nurse Practitioner (NP) - Vandalia, Missouri (79610)
Nurse Practitioner - Jefferson City, MO - Part Time - 3 days per week
Commonwealth Medical ServicesEmployer score · GoldJefferson City, MO
Full-time, Nurse Practitioner (NP) - Boonville, Missouri (78353)
Field Nurse Practitioner - St. Louis County, MO
AdvantmedEmployer score · SilverMissouri
Nurse Practitioner - F/T - Watson Primary Care
Esse HealthEmployer score · SilverSt. Louis, MO
Nurse Practitioner - P/T or F/T - South County - Gastroenterology
Esse HealthEmployer score · SilverSt. Louis, MO
Full-time HouseCalls Nurse Practitioner - Crawford and Phelps Counties, MO
UnitedHealth GroupEmployer score · SilverMissouri
Full-time, Nurse Practitioner (NP) - Bonne Terre, Missouri (76738)
Centurion HealthBonne Terre, MO
Care Manager - Nurse Practitioner - PRN
Esse HealthEmployer score · SilverSt. Louis, MO
Nurse Practitioner - F/T - Watson Primary Care
Esse HealthEmployer score · SilverSt. Louis, MO
Nurse Practitioner or Physician Assistant - F/T - Fenton - Dr. Kolli's Office
Esse HealthEmployer score · SilverFenton, MO
Nurse Practitioner or Physician Assistant - P/T or F/T - Fenton Family Medicine
Esse HealthEmployer score · SilverFenton, MO
$5,000 Signing Bonus - Full-time Nurse Practitioner - St. Joseph, MO (76272)
Centurion HealthSt. Joseph, MO
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How Missouri Compares for Nurse Practitioner Pay
Missouri against neighboring states and the top payers, from our own nurse practitioner postings over the last 12 months — not a salary survey.
Nurse Practitioner roles in Missouri advertise $6k below the $135k median across the 51 states we can measure, where California leads at $163k.
| State | Median pay | vs MO | WLB | Listings |
|---|---|---|---|---|
| Missouri (this page) | $128k | — | 5.6/10 | 771 |
| Kansasborders | $136k | +$7k | 5.6/10 | 297 |
| Illinoisborders | $135k | +$6k | 5.4/10 | 1589 |
| Oklahomaborders | $129k | +$1k | 5.1/10 | 354 |
| Arkansasborders | $126k | −$3k | 5.1/10 | 381 |
| Iowaborders | $125k | −$3k | 5.2/10 | 446 |
| Kentuckyborders | $125k | −$4k | 5.3/10 | 402 |
| Nebraskaborders | $122k | −$6k | 5.2/10 | 184 |
“borders” = shares a border with Missouri; “#n” = national pay rank among the 51 measured states.
Nurse Practitioner Jobs in Missouri: Market Overview & Work-Life Balance
Listing snapshot: this overview summarizes the jobs loaded on this page. Market comparisons use the separate scope and time period labeled in their section.
Missouri offers a competitive market for healthcare professionals seeking nurse practitioner jobs in missouri. With 316+ open positions, clinicians have strong options for career growth and work-life balance.
Every listing is evaluated using WeekdayDoc's proprietary work-life balance scoring system. Nurse Practitioner Jobs in Missouri on this page have an average score of 8.2/10, with 59% with no on-call requirements, 100% with no weekends, 6% offering remote work. This data helps clinicians quickly identify positions that match their lifestyle priorities without reading through hundreds of job descriptions.
Leading employers currently hiring for nurse practitioner jobs in missouri include Esse Health, Centurion Health, BJC HealthCare, Commonwealth Medical Services, and more. Positions span nurse practitioner jobs missouri. New jobs are added daily as healthcare organizations expand their teams.
Among the top-rated employers hiring for nurse practitioner jobs in missouri, BetterHelp (score: 95.9/100), Talkiatry (score: 95.0/100), Hiaah (score: 94.5/100) have earned WeekdayDoc's Top Employer designation based on our proprietary ranking system. This ranking evaluates burnout scores (40%), salary competitiveness (30%), and work-life balance features like no-call and remote options (30%). See the full rankings on our Top Employers page.
According to WeekdayDoc's Market Pulse — which tracks real-time compensation data from thousands of active job postings — the current median salary is $105K, trending up 3.4% over the past quarter. This data is derived from 31,769+ job postings analyzed over the past 12 months — updated daily, unlike annual survey-based reports. Explore salary trends and burnout data on our Market Pulse dashboard.
A few things worth knowing
About Nurse Practitioner jobs in Missouri.
How much do nurse practitioners earn in Missouri?
A reliable salary estimate is unavailable for this sample of nurse practitioners. Compensation varies by role, specialty, location, and schedule. Compare employer-posted pay where disclosed, including its currency and pay period; missing pay is not estimated.
Are there remote or hybrid nurse practitioners jobs available?
Yes — about 6% of current nurse practitioners listings offer remote or hybrid work. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.
Which nurse practitioners jobs have the best work-life balance?
Every nurse practitioner role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 59% with no on-call and 100% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.
Who is hiring nurse practitioners in Missouri right now?
Employers currently hiring for nurse practitioner roles include Esse Health, Centurion Health, BJC HealthCare, Commonwealth Medical Services, and others. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.
How many nurse practitioner jobs in missouri are available, and how often are they updated?
There are currently 316 nurse practitioners positions in Missouri listed, with new roles added as employers post them. Job descriptions are public. Verified sign-in with Google or email gives free access to regular Apply, full search, and standard Market Insights. Saved jobs, My Search, and the dashboard also require verified sign-in. Eligible featured employer listings allow Apply without signup or email. Basic calculators are public and free; optional AI contract analysis, RVU Billing Optimizer, and Schedule Optimizer reports remain paid.
Employers hiring now
Organizations with the most openings in Nurse Practitioner Jobs in Missouri
CVS Health40 open roles here · WLB 61/100
Washington University in St. Louis25 open roles here · WLB 67/100
BJC HealthCare21 open roles here · WLB 52/100
Esse Health17 open roles here · WLB 61/100UnitedHealth Group17 open roles here · WLB 70/100
CoxHealth13 open roles here · WLB 66/100
GoHealth Urgent Care7 open roles here · WLB 68/100