Esse Health logo
Esse Health
St. Peters, Missouri

Nurse Practitioner or Physician Assistant - F/T - St. Peters & Florissant

Nurse PractitionerIncludes callIncludes weekendsNo nightsFull-Time Physician-Supervised State

Listed compensation

$95k-$125k

The week · per this posting · Monday – Friday

Weekend work is also flagged as required; confirm which days and how often.

Ask the employer about the work setting and time off.

Posted 56m ago · Verified live

Job Description

Esse Health is the largest independent physician practice in the St. Louis

Metropolitan area with over 100+ physicians, in 35+ locations, serving nearly

130,000 patients. We are leading the healthcare community by placing patients and their physicians at the center of health decisions. Esse Health is more than a healthcare provider - it's a place where medicine is a calling and not just a profession. It's a team of extraordinary medical professionals with the latest ideas for keeping patients healthier.

Practice with independence and at the highest level of your training!

Join Our Team

Esse Health is currently seeking a compassionate full-time Advanced Practice

Provider (NP/PA) for our office of Dr.'s Knapp & Miranda!

Opportunity

  • Full-time opening
  • Monday - Friday, 8 hours a day (Fridays may be a bit shorter)
  • 2 days at St. Peters office location (4800 Mexico Road) & 3 days at

Florissant office location (2187 Charbonier Road)

  • No nights, weekends, or holidays
  • Outpatient focused clinical practice
  • Call approximately one weekend a month (low volume)

Day-to-Day

  • Join a collaborative team and develop a 1:1 relationship with patients and clinical staff members
  • Provide comprehensive primary care services to adult patients
  • Conduct patient evaluations, physical exams, and diagnostic assessments
  • Diagnose and manage acute and chronic conditions
  • Develop and implement treatment plans in collaboration with physician partner
  • Emphasize preventive care, wellness, and patient education
  • Document patient care accurately and efficiently in the electronic health record (NextGen)
  • Coordinate care with specialists and other members of the healthcare team
  • Participate in quality improvement and care coordination initiatives

Qualifications

  • Master’s Degree of Science in Nursing or Physician Assistant-Master’s Degree
  • Current Nurse Practitioner or Physician Assistant licensure in Missouri (or eligibility)
  • Certified Physician Assistant or Certified Nurse Practitioner (or eligibility)
  • Strong clinical, communication, and interpersonal skills
  • Commitment to patient-centered, team-based care
  • Ability to work independently while collaborating closely with physicians

What We Offer

  • Physician-led, supportive practice environment
  • Competitive compensation: The starting salary for entry level will likely be in the $95,000 - $112,000 range (factors may include candidate experience and specific role within the office). Up to $125,000/year may be considered for candidate's with an average of 8 -10 years of NP/PA experience.
  • Benefits within your first 30 days
  • Available benefits: Medical, Dental, Vision, Life, Long/Short Term
  • Disability, Health Savings Account/Flexible Spending Account, Fraud
  • Protection, Legal, Pet and other miscellaneous
  • Generous PTO policy + 9 paid holidays
  • 401k match + profit sharing
  • Tuition reimbursement
  • Wellness program
  • Opportunities for professional growth and mentorship
  • Emphasis on work-life balance
  • Modern facilities and integrated care teams

EOE

Key Responsibilities

Provide comprehensive primary care services to adult patients, including conducting physical exams and managing acute and chronic conditions. Collaborate with physician partners to develop treatment plans and coordinate care within an integrated team environment.

Qualifications

Education
Professional certificate or licensure
Experience
5+ years of experience

Key Skills

Patient evaluationAcute condition managementChronic condition managementTreatment planningElectronic health record documentation

Family Medicine — Nurse Practitioner Career Context

Of the 50 active Family Medicine listings this role was benchmarked against, 16% are remote, 62% have no call, 80% require no weekends.

The cost-of-living index for Missouri is 90.8 (US average = 100; BEA Regional Price Parities (2024)), so the posted ~$110k midpoint carries the purchasing power of roughly $121k in an average-cost state. 60.1% of Missouri clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

What does the Family Medicine market look like in Missouri?
MeasureThis jobMarket
Work-life score6.4 / 10 · above average in nurse practitioner rolesranked against 13,998 Nurse Practitioner roles listingslisting-based score, 0–10
Cost-of-living adjusted pay~$121k in purchasing powerMissouri index 90.8 (US = 100)BEA Regional Price Parities (2024)
Family Medicine listings in Missouri94 active2,685 nationallylive on WeekdayDoc, Oct 2026
Work settingon-sitepeers: 16% remote · 62% no call · 80% no weekends50 benchmarked listings
Esse Healthsilver tier, 79/100 · #14 of 14 for payTop Employers work-life index33 active listings
Sources: WeekdayDoc live listing index (13,998 Nurse Practitioner roles listings), Top Employers work-life index, BEA Regional Price Parities (2024); as of Oct 2026. Same values as the Weekday Verdict and Market Insights on this page.

Work-Life Balance Analysis

WeekdayDoc's proprietary algorithm rates Nurse Practitioner or Physician Assistant - F/T - St. Peters & Florissant at Esse Health a 6.4 out of 10 for work-life balance — classified as good. This places the position in the Above average in Nurse Practitioner roles — ranked against 13,998 active Nurse Practitioner roles listings on WeekdayDoc. Contributing factors include no night shifts.

Top Nurse Practitioner Jobs

24 matches · ranked by pay

Salary Distribution

24 jobs · 18 employers
6
<$140k
6
$140k-155k
10
$155k-170k
0
$170k-185k
2
$185k+

Annual compensation range

Benefits & Perks

23 jobs · 18 employers
401k / retirement match
91% this job
Sign-on bonus
52%
CME allowance
52%
Loan repayment
22%
Relocation assistance
4%

Share of similar jobs offering each benefit

#1

Virtual Behavioral Health PMHNP - California License Required

Iris Telehealth for Providers · Los Angeles, California

Starting at $200,000
#2

Nurse Practitioner, Advanced Practice Provider

CVS Health · Independence, Missouri

$87k-$187k
#3

NP - Integrative Health - Duluth, MN

$121k-$169k
#4

Virtual Clinician Home Evaluations Nurse Practitioner or Physician Assistant (Full Time) - Nebraska

$78k-$169k
+ 22 more · ranked by pay

Work-life snapshot

median 6.4this job 6.4
Better work-life than 50% of Family Medicine (NP) listings

Listing-based score, 0–10, across 2,640 comparable listings. Shaded area = the share scoring below this one.

  • No nights
  • On-site
  • Includes call
  • Includes weekends
Esse Health logo

About Esse Health

Medical Practices
St. Louis, Missouri
501-1,000 employees

Benefits & Perks

Medical, Dental, Vision
Life and Disability Insurance
Health Savings Account/Flexible Spending Account
401k match + profit sharing
Generous PTO policy + 9 paid holidays
Tuition reimbursement
Wellness program
Work-life balance emphasis

Living in St. Peters

Typical 3-bedroom home value
$319k≈ 3.4× annual pay
Typical market rent
$1,687/mo≈ 21% of gross pay
Residents’ average commute
23 min
Metro price indexU.S. average = 100
95.1
State income tax
Up to 5.3%
Sources & methodology

Sources: Zillow home values (Sep 2026), Zillow market rents (Sep 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · St. Louis, MO-IL metro prices. Housing figures are city-level.

Ratios use this listing’s gross annual pay. Not a cost-of-living guarantee.