229+ Nurse Practitioner Jobs in South Carolina
Nurse Practitioner positions in South Carolina with $100K-$150K salary ranges, burnout scores, and schedule details shown upfront. Filter by no call, remote, and weekday-only.
229+ positions available
229+ Nurse Practitioner Jobs in South Carolina Available Now
These 58 roles pay ~$146k median with 6.5/10 median work-life balance — use these as your benchmarks.
Office Nurse Practitioner - Lexington Health Family Practice
Lexington Medical Center
6.4/10
6.4/10
Advanced Practice Provider (APP) - Nurse Practitioner or Physician Assistant - Family Medicine
ZohorecruitGreat Workplace
6.3/10
Psychiatric Nurse Practitioner (PMHNP) - Child/Adolescent
LifeStance HealthTop Employer
6.3/10
in Urgent Care (NP)
Urgent Care Nurse Practitioner or Physician Assistant- West Ashley/Charleston, SC
WellStreet Urgent CareGreat Workplace
in Urgent Care (NP)
Urgent Care Nurse Practitioner or Physician Assistant- West Columbia, SC
WellStreet Urgent CareGreat Workplace
in Urgent Care (NP)
in Hospice And Palliative Care (NP)
Experienced PMHNP or Psychiatric PA | Outpatient Psychiatry | FT | M–F
Ally Psychiatry
6.0/10
Urgent Care Nurse Practitioner or Physician Assistant- Columbia, SC (Float)
WellStreet Urgent CareGreat Workplace
Nurse Practitioner / Physician Assistant Family Med Peds Wade Hampton
Prisma Health
APP Fellow (Nurse Practitioner or Physician Assistant) - Hematology Oncology
MUSC
in Hospital Medicine (NP)
A nurse practitioner in south carolina role paying $1,800 - $11,500/mo with no call is hidden in this list.
228 more hidden below, ranked by pay and work-life.
Nurse Practitioner (PRN) - In-Home Health Assessments
Negotiation brief with every application
Your counter number + word-for-word script
One-time payment · dashboard + negotiation brief on every application
2 more roles in this search — preview locked listings
How South Carolina Compares for Nurse Practitioner Pay
South Carolina against neighboring states and the top payers, from our own nurse practitioner postings over the last 12 months — not a salary survey.
Nurse Practitioner roles in South Carolina advertise $5k below the $138k median across the 51 states we can measure, where North Dakota leads at $173k.
| State | Median pay | vs SC | WLB | Listings |
|---|---|---|---|---|
| South Carolina (this page) | $133k | — | 5.5/10 | 664 |
| North Dakota#1 | $173k | +$40k | 5.6/10 | 43 |
| California#2 | $166k | +$33k | 5.6/10 | 2161 |
| Alaska#3 | $158k | +$25k | 6.9/10 | 43 |
| Washington#4 | $153k | +$19k | 5.8/10 | 629 |
| Hawaii#5 | $151k | +$17k | 5.8/10 | 44 |
| Georgiaborders | $132k | −$2k | 5.2/10 | 827 |
| North Carolinaborders | $127k | −$7k | 5.6/10 | 867 |
“borders” = shares a border with South Carolina; “#n” = national pay rank among the 51 measured states.
South Carolina Jobs
229+ nurse practitioner positions in South Carolina
Competitive Pay
Earn $100K-$150K with benefits
Updated Daily
New positions added daily
Nurse Practitioner Jobs in South Carolina: Salary, Outlook & Work-Life Balance
South Carolina offers a competitive market for healthcare professionals seeking nurse practitioner jobs in south carolina. With 229+ open positions and salaries ranging from $135K to $364K, clinicians have strong options for career growth and work-life balance.
Every listing is evaluated using WeekdayDoc's proprietary work-life balance scoring system. Nurse Practitioner Jobs in South Carolina on this page have an average score of 5.8/10, with 10% with no on-call requirements, 45% with no weekends. This data helps clinicians quickly identify positions that match their lifestyle priorities without reading through hundreds of job descriptions.
Leading employers currently hiring for nurse practitioner jobs in south carolina include MUSC, WellStreet Urgent Care, Lexington Medical Center, Prisma Health, and more. Positions span nurse practitioner jobs south carolina. New jobs are added daily as healthcare organizations expand their teams.
Among the top-rated employers hiring for nurse practitioner jobs in south carolina, Sailor Health (score: 97.0/100), GLOBAL OUTREACH TELEREHABILITATION (score: 96.8/100), Talkiatry (score: 96.4/100) have earned WeekdayDoc's Top Employer designation based on our proprietary ranking system. This ranking evaluates burnout scores (40%), salary competitiveness (30%), and work-life balance features like no-call and remote options (30%). See the full rankings on our Top Employers page.
According to WeekdayDoc's Market Pulse — which tracks real-time compensation data from thousands of active job postings — the current median salary is $105K. This data is derived from 68,498+ job postings analyzed over the past 12 months — updated daily, unlike annual survey-based reports. Explore salary trends and burnout data on our Market Pulse dashboard.
Frequently Asked Questions
How much do nurse practitioners earn in South Carolina?
Listed nurse practitioners in South Carolina on WeekdayDoc pay roughly $135K to $364K per year, with a median near $142K. Actual pay varies by specialty, setting, experience, and shift type — every listing shows its salary upfront.
Are there remote or hybrid nurse practitioners jobs available?
Some nurse practitioners roles offer remote or hybrid flexibility. You can filter for telehealth and work-from-home options, and every listing shows its remote status before you apply.
Which nurse practitioners jobs have the best work-life balance?
Every nurse practitioner role on WeekdayDoc is scored for burnout risk using call schedule, weekend and night requirements, and remote flexibility. Among current listings, 10% with no on-call and 45% with no weekends. You can sort by work-life-balance score to surface the lowest-burnout roles first.
Who is hiring nurse practitioners in South Carolina right now?
Employers currently hiring for nurse practitioner roles include MUSC, WellStreet Urgent Care, Lexington Medical Center, Prisma Health, and others. WeekdayDoc aggregates verified openings from these and other organizations, refreshed daily.
How many nurse practitioner jobs in south carolina are available, and how often are they updated?
There are currently 229+ nurse practitioners positions in South Carolina listed, with new roles added daily as employers post them. Create a free account to compare salaries and work-life-balance scores side by side, then apply directly.
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