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Amgen
Thousand Oaks, California

Asset Lead Medical Director - Obesity and Related Conditions

Medical AffairsFull-Time

Listed compensation

$218k-$294k

The week · per this posting · weekdays assumed

Ask the employer about call expectations, weekend coverage, nights and shift pattern and time off.

Posted 1h ago · Verified live

Job Description

Career Category

Medical Affairs

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Asset Medical Lead Medical Director – Cardiovascular & Metabolic (CVM) Strategy

What You Will Do

Let’s do this. Let’s change the world.

In this vital role, you will lead the development and delivery of U.S. Cardiovascular & Metabolic (CVM) Medical strategy for maridebart cafraglutide (also known as MariTide), an investigational therapy developed by Amgen and being studied for obesity and obesity-related conditions.

You will establish the cross-indication scientific, evidence, stakeholder, and implementation foundation that supports chronic weight management (CWM) launch readiness and prepares the organization for maturation in CVM.

In partnership with the U.S. Medical Portfolio Lead, TA Head, Global Medical, and cross-functional colleagues, you will translate global strategy into an integrated U.S. Medical plan.

Responsibilities

  • Lead U.S. CVM Medical strategy, with initial emphasis on CWM launch support and early CV readiness.
  • Build an integrated, evidence-based CVM narrative linking obesity and the broader care continuum.
  • Define U.S. scientific evidence gaps and shape local evidence, RWE, HEOR, and Access and Use Evidence Generation priorities in alignment with global plans.
  • Synthesize customer, field, market, and medical insights to inform U.S. Medical, Brand, evidence, and implementation decisions.
  • Develop the early external-engagement plan for cardiologists, HF specialists, integrated delivery networks, professional societies, payers, and other priority stakeholders.
  • Partner with Global Medical, Global Development, CfOR, HEOR, Medical Value and Access, and Scientific Communications to translate emerging evidence into U.S. strategy and execution.
  • Lead or support U.S. scientific communications, including the scientific platform, core content, publication implementation, congress plans, and medical education.
  • Support clinical trial activities and data interpretation as a U.S. Medical interface with Global Clinical Development and evidence-generation teams.
  • Lead or support advisory boards, expert panels, and implementation-science initiatives that clarify real-world care pathways, referral patterns, and barriers to appropriate care.
  • Provide medical input into reimbursement, policy, regulatory, label, and promotional-material discussions consistent with governance and evidence.
  • Serve as a medical representative in leadership, governance, launch-readiness, and cross-functional teams; recommend priorities and resource trade-offs for the U.S. Medical plan.
  • Contribute to medical training and field scientific readiness for CWM/OSA and evolving CVM evidence needs.
  • Support decisions on independent medical education, medical grants, sponsorships, and advocacy activities in accordance with Amgen governance.
  • Ensure Medical activities comply with applicable laws, regulations, policies, and standard operating procedures.
  • Use established planning and performance-management processes to measure progress, identify risks, and improve execution.

What We Expect of You

We are all different, yet we all use our unique contributions to serve patients. The Medical Affairs Asset Lead we seek is a strategy leader with these qualifications.

Basic Qualifications

Doctorate degree and 4 years of Medical Affairs, clinical research, or cardiometabolic science research experience

  • OR
  • Master’s degree and 7 years of Medical Affairs, clinical research, or cardiometabolic science research experience
  • OR

Bachelor’s degree and 9 years of Medical Affairs, clinical research, or cardiometabolic science research experience

Preferred Qualifications

PharmD, PhD, MD, or other advanced scientific or clinical degree with experience in cardiometabolic disease, obesity, cardiovascular disease, heart failure, or related conditions.

Strong clinical and scientific knowledge of cardiometabolic disease, including obesity and its related conditions.

Experience in U.S. Medical Affairs within the biopharmaceutical industry, including scientific engagement with cardiologists, endocrinologists, obesity-medicine clinicians, integrated delivery networks, and/or payers.

Experience developing or implementing medical strategy, evidence-generation plans, RWE, HEOR, or access-and-use evidence in a matrixed organization.

Knowledge of pharmaceutical product development, lifecycle planning, launch readiness, and collaboration across Clinical Operations, Commercial, Regulatory, Market Access, and Medical Affairs.

Experience engaging external experts, professional societies, advocacy organizations, health systems, and payers for scientific exchange and insight generation.

Ability to integrate multiple indications, scientific narratives, and stakeholder needs into a clear U.S. Medical strategy.

Familiarity with global regulatory organizations, guidelines, and practices, including Good Clinical Practice requirements.

  • Sound judgment, strong communication skills, and a track record of solving complex cross-functional problems.
  • Demonstrated success leading through influence and working across matrixed, cross-functional teams.

What You Can Expect of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives

Award-winning Time-off Plans

Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team. careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application Deadline

  • Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
  • Sponsorship
  • Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.

We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation..

Salary Range

217,673.10USD -294,498.90 USD

Requirements

Candidates must hold a doctorate, master's, or bachelor's degree with 4 to 9 years of relevant experience in medical affairs or clinical research. Preferred qualifications include an advanced scientific or clinical degree (MD, PhD, PharmD) and specific expertise in cardiometabolic disease and biopharmaceutical medical strategy.

Qualifications

Education
Doctoral or professional degree (postgraduate degree)
Experience
10+ years of experience

Key Skills

Stakeholder engagementScientific communicationRegulatory compliance

Medical Affairs — Physician Career Context

The cost-of-living index for California is 110.7 (US average = 100; BEA Regional Price Parities (2024)), so the posted ~$256k midpoint carries the purchasing power of roughly $231k in an average-cost state. 63.6% of California clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

Medical Affairs pay on WeekdayDoc is up 10.2% vs. the prior quarter (through Sep 2026).

What does the Medical Affairs market look like in California?
MeasureThis jobMarket
Listed pay$218k–$294kMedical Affairs median $306k (middle half $285k–$338k)17 comparable listings, Oct 2026
Cost-of-living adjusted pay~$231k in purchasing powerCalifornia index 110.7 (US = 100)BEA Regional Price Parities (2024)
Medical Affairs listings in California43 active298 nationallylive on WeekdayDoc, Oct 2026
Sign-on & loan repaymentsign-on bonusCalifornia Physician listings: 31% state a sign-on bonus (median $100k) · 27% offer loan repayment1,000 active listings, Oct 2026
Medical Affairs pay trend+10.2% vs prior quarter—through Sep 2026
Sources: WeekdayDoc live listing index, BEA Regional Price Parities (2024); as of Oct 2026. Same values as the Weekday Verdict and Market Insights on this page.

Top Medical Affairs Jobs

2 matches · ranked by pay
#1

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#2

Sr. Medical Director (Neurologist)

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Work-life snapshot

median 3.0this job 1.5
Below most Medical Affairs listings for work-life

Listing-based score, 0–10, across 293 comparable listings. Shaded area = the share scoring below this one.

  • On-site
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About Amgen

Biotechnology Research
Thousand Oaks, CA
10,000+ employees

Benefits & Perks

Retirement and Savings Plan with generous company contributions
Group medical, dental, and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible

Living in Thousand Oaks

Typical 3-bedroom home value
$904k≈ 4.2× annual pay
Typical market rent
$3,357/mo≈ 19% of gross pay
Residents’ average commute
25 min
Metro price indexU.S. average = 100
110.5
State income tax
Up to 13.3%
Sources & methodology

Sources: Zillow home values (Sep 2026), Zillow market rents (Sep 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · Oxnard-Thousand Oaks-Ventura, CA metro prices. Housing figures are city-level.

Ratios use this listing’s gross annual pay. Not a cost-of-living guarantee.