Irvine Clinical Research logo
Irvine Clinical Research
Long Beach, California

Sub-Investigator (NP or PA) - Long Beach

Nurse PractitionerNo weekendsNo nightsFull-Time Physician-Supervised State

Listed compensation

$125k-$140k

The week · per this posting · weekdays assumedWeekdays only

Ask the employer about the work setting, call expectations and time off.

Posted 1mo ago · Verified live

Job Description

Healthy Brain Clinic in Long Beach, CA is part of the Irvine Clinical Research site network, the largest of its kind on the West Coast. With 5 research centers in California, we are leaders in the search for new treatments in neurology, psychiatry, and obesity medicine.

Our largest area of research is in Alzheimer's Disease prevention and treatment drug trials, and our doctors were the largest contributors in the world to the most recently FDA-approved medication in Alzheimer's Disease.

We are hiring a clinical investigator--either a Nurse Practitioner (NP) or Physician Assistant (PA)--to join our Healthy Brain Clinic / Long Beach team. The clinician will oversee and conduct clinical trials of some of the most promising drugs under investigation in Alzheimer's Disease treatment and prevention, driving clinical excellence at our growing Long Beach site.

Job Duties

Clinical Trial Execution: Oversee and conduct protocol-driven clinical trial visits as a Sub-Investigator, ensuring strict adherence to FDA regulations, GCP guidelines, and study protocols.

Participant Eligibility & Medical Oversight: Conduct physical and neurological examinations, medical history assessments, clinical intake evaluations, and diagnostic reviews to evaluate participant safety and study eligibility.

IV Line Placement & Infusions: Directly insert peripheral IV lines, administer investigational intravenous medications, and manage participant care and monitoring throughout active infusion procedures.

Participant Safety & Event Management: Monitor study participant safety throughout trial participation, managing and reporting adverse events in a thorough and timely manner.

Collaborative Research Team: Partner closely with Principal Investigators, fellow Sub-Investigators, clinical research coordinators, and study raters to ensure quality trial delivery.

Job Requirements

Licensure

Active, unencumbered license to practice as a Nurse Practitioner (NP) or Physician Assistant (PA-C) in California.

Clinical Skills: Demonstrated proficiency and hands-on skill in IV placement and intravenous infusions.

Patient Population: Clinical experience working with older adult populations in a primary care, specialty, or clinical research environment.

Research Experience: Prior experience as a Sub-Investigator or Clinical Research Coordinator in pharmaceutical industry trials is preferred, but not required.

Communication & Precision: Professional command of written and spoken English, with strong clinical documentation skills and a compassionate patient-facing demeanor.

$125,000 - $140,000 a year

Schedule & Hours

Full-time or part-time (minimum 20 hours per week). All hours are during normal weekday business hours with no planned overnight or weekend shifts.

Location

On-site at our Healthy Brain Clinic location in Long Beach: 1703 Termino Ave, Ste 201, Long Beach, CA 90804. Located in a modern medical building near the Traffic Circle with ocean views, convenient transit/freeway access, and ample free parking.

Network Integration: While anchored at our Long Beach site, opportunities for cross-coverage, regional investigator training, or multi-site trial support across our California network may be available.

Salary Range: $125,000/yr ($60.00/hr) to $140,000/yr ($67.31/hr). Placement within the range is based on experience, with higher starting compensation reserved for experienced Sub-Investigators in CNS, neurology, or psychiatry clinical trials.

Insurance: The company covers 100% of employee-only individual premiums for our baseline Gold HMO health plan, plus dental and vision coverage for eligible full-time staff.

Paid Time Off: 3 weeks of paid vacation (PTO) per year, plus paid sick leave and company holidays.

Equal Opportunity Employer

Healthy Brain Clinic and its affiliates are Equal Opportunity Employers. We evaluate all qualified applicants without regard to race, color, religion, sex, national origin, age, disability, sexual orientation, gender identity, or any other status protected by CA state or federal law.

Key Responsibilities

The clinician will oversee and conduct protocol-driven clinical trial visits, ensuring strict adherence to FDA regulations and GCP guidelines. They will also perform physical and neurological examinations, manage participant safety, and administer investigational intravenous medications.

Requirements

Candidates must hold an active, unencumbered license as a Nurse Practitioner or Physician Assistant in California. Proficiency in IV placement and intravenous infusions is required, along with experience working with older adult populations.

Qualifications

Experience
2+ years of experience

Key Skills

Medical history assessmentAdverse event reportingPatient safety monitoringProtocol adherenceDiagnostic review

Neurology — Nurse Practitioner Career Context

Of the 50 active Neurology listings this role was benchmarked against, 16% are remote, 72% have no call, 70% require no weekends.

The cost-of-living index for California is 110.7 (US average = 100; BEA Regional Price Parities (2024)), so the posted ~$133k midpoint carries the purchasing power of roughly $120k in an average-cost state. 63.6% of California clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

Neurology pay on WeekdayDoc is up 5.9% vs. the prior quarter (through Sep 2026).

Work-Life Balance Analysis

WeekdayDoc's proprietary algorithm rates Sub-Investigator (NP or PA) - Long Beach at Irvine Clinical Research a 6.5 out of 10 for work-life balance — classified as good. This places the position in the Above average in Neurology (NP) — ranked against 141 active Neurology (NP) listings on WeekdayDoc. Contributing factors include no weekend requirements, no night shifts.

Top Nurse Practitioner Jobs

30 matches · ranked by pay

Salary Distribution30 jobs · 26 employers

12
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1
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Annual compensation range

Benefits & Perks25 jobs

401k / retirement match
80%
Sign-on bonus
56%
CME allowance
56%
Relocation assistance
24%
Loan repayment
20%

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Work-life snapshot

median 6.4this job 6.5
Better work-life than 50% of Neurology (NP) listings

Listing-based score, 0–10, across 141 comparable listings. Shaded area = the share scoring below this one.

  • No weekends
  • No nights
  • On-site

Living in Long Beach

Typical 3-bedroom home value
$961k≈ 7.7× annual pay
Typical market rent
$2,422/mo≈ 23% of gross pay
Residents’ average commute
30 min
Metro price indexU.S. average = 100
113.6
State income tax
Up to 13.3%
Sources & methodology

Sources: Zillow home values (Aug 2026), Zillow market rents (Aug 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · Los Angeles-Long Beach-Anaheim, CA metro prices. Housing figures are city-level.

Ratios use this listing’s gross annual pay. Not a cost-of-living guarantee.

Irvine Clinical Research logo

About Irvine Clinical Research

Biotechnology Research
Irvine, CA
11-50 employees

Benefits & Perks

100% employer-paid Gold HMO health plan
Dental and vision coverage
3 weeks paid vacation
Paid sick leave
Company holidays