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UPMC
Harrisburg, Pennsylvania

Professional Staff Nurse, ONC (RN) - Nurse Navigator

Registered NurseFull-Time

Compensation

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Job Description

UPMC Hillman Cancer Center – Professional Staff Nurse, ONC (RN)

Harrisburg, PA | Regular, Full‑Time

UPMC Hillman Cancer Center is seeking a Professional Staff Nurse, Oncology (RN) to support our fast‑paced and growing infusion center in Harrisburg, PA. This is a unique cross‑trained role that blends infusion nursing with nurse navigation. This position is ideal for an RN who values meaningful patient relationships, interdisciplinary teamwork, and opportunities to grow their clinical skill set.

In this role, you will be trained to provide safe, high‑quality infusion services while also serving as a supportive guide for patients throughout their oncology care journey. You’ll be a key part of the care team, working closely with providers and clinical staff to deliver patient‑centered care. You will act as an advocate for patients and their families, ensuring they receive the support, education, and resources they need.

This position will also play an important role in UPMC Hillman's expanding bispecific therapy program (BITE). Bispecific therapies use advanced antibody treatments designed to target both cancer cells and immune cells simultaneously, enhancing the body's ability to recognize and fight cancer.

As these innovative treatments continue to transform cancer care, nurses in this role will be involved in the administration and monitoring of patients receiving bispecific therapies, providing specialized assessment, education, and management of potential neurologic and immune-related side effects.

This offers a unique opportunity to work at the forefront of cutting-edge oncology treatment and contribute to advancing cancer care in our region.

  • Schedule & Flexibility
  • Days: Vary
  • Flexible scheduling required
  • Must be willing to work 8‑, 10‑, and/or 12‑hour shifts to meet a 40‑hour workweek
  • Start times vary and flexibility is essential to support clinic operations

Clinic Hours

  • Mondays & Fridays: 7:00 AM – 5:30 PM
  • Tuesdays, Wednesdays & Thursdays: 7:00 AM – 7:30 PM
  • Start times for this position may be 7:00 AM, 7:30 AM, or 8:00 AM.

Placement within the UPMC nursing career ladder and starting salary will be based on education and experience, offering opportunities for professional growth within the organization.

Interested in learning more about oncology nursing and working with one of the nation’s leading cancer programs?

Check out the UPMC Hillman Cancer Center Oncology Nursing Blog to learn more about our nurses and their impact.

Responsibilities

Actively participates in department or unit-specific quality improvement efforts. Identifies opportunity for quality improvement to colleagues and management. Takes personal responsibility in improving patient satisfaction with the quality of care and service.

Utilizes research and evidence-based practice to support improvement in clinical care: identifies research issues or articles related to clinical specialty or areas of interest, discusses opportunities for quality improvement at multidisciplinary rounds, and influences patients' plans of care.

Demonstrates accountability for professional development that improves the quality of professional practice and the quality of patient care. Actively participates in unit-based shared governance, goal setting and supports the change and transition process to improve quality of care and the practice environment.

Serves as a highly engaged and full partner on the care team and responds willingly to care team member needs for assistance and partnership. Participates in work that improves patient care and the professional practice environment. Adapts to change and demonstrates flexibility with the change process.

Develops and maintains productive working relationships internally and externally by demonstrating accountability for actions, enthusiasm, motivation and commitment to patients and colleagues. Demonstrates an understanding of cultural differences and holds peers accountable for healthy relationships.

Maintains a conscious balance between work and personal life. Models safe work hours, time management and healthy lifestyle. Communicates with peers and management any safety hazards identified in the workplace.

Demonstrates knowledge of adult learning principles (and/or teaching children if applicable) and applies in teaching of patients, families, students and new staff.

Provides detailed and appropriate teaching to patients and families to effectively guide them through the episode of care as well as transition to another level of care and/or home. Supports the development of students, new staff and colleagues, may serve as a preceptor.

Creates an environment of open dialogue, inquiry and continuous development by asking for feedback and improving practice.

Applies the nursing process within the framework of Relationship Based Care to create a healing environment. Formulates daily goals and a plan of care for patients that involves the patient as partner and considers the individual needs of the patient in a holistic manner.

Demonstrates critical thinking in the identification of clinical, social, safety, psychological and spiritual issues for the patient care within an episode of care.

Practices solid communication skills, and is able to articulate and translate the patient's condition to other care providers and to negotiate and make recommendations for changes in patient care and unit practices. Patient documentation is comprehensive and promotes communication between caregivers.

Incorporates national professional organization as well as business unit and health system's goals to improve patient safety, quality and satisfaction. Creates a caring and compassionate patient focused experience by building healing relationships with patients, families and colleagues.

The individual must be able to demonstrate the knowledge and skills necessary to provide care and/or interact appropriately to the ages of the patients served by his/her assigned unit as specified below. They must also demonstrate knowledge of the principles of growth and development over the life span and possess the ability to assess data reflective of the patient's status and interpret the appropriate information needed to identify each patient's requirements relative to his/her age-specific needs and to provide the care needs as described in the department policy and procedures.

Minimum 6 months experience.

BSN preferred.

Ability to establish and maintain positive, caring relationships with executives, managers, physicians, non-physician providers, ancillary and support staff, other departments, and patients/families.

Ability to work productively and effectively within a complex environment, handle multiple/changing priorities and specialized equipment.

Good clinical judgment with critical thinking, analytical and problem solving abilities required as related to various aspects of patient care.

  • Critical thinking skills necessary to exercise and to lead others in application of the nursing process.
  • Mobility and visual manual dexterity.
  • Physical stamina for frequent walking, standing, lifting and positioning of patients.

Licensure, Certifications, and Clearances

UPMC approved national certification preferred. Current Pennsylvania licensure as a Registered Professional Nurse in PA, OH or NY required. CPR required based on AHA standards that include both a didactic and skills demonstration component within 30 days of hire.

  • Basic Life Support (BLS) OR Cardiopulmonary Resuscitation (CPR)
  • Registered Nurse (RN) OR Temporary Practice Permit (TPP)
  • Act 34

*Current licensure either in the state where the facility is located or, if the facility is in a state covered by the multistate Nursing Licensure Compact (NLC) agreement, a multistate license issued by a participating NLC state. Hires and current employees working on an out-of-state NLC license who later change their residency to the state where the facility is also located will have 60 days upon changing their residency to apply for licensure within that state.

UPMC is an Equal Opportunity Employer/Disability/Veteran

Requirements

Candidates must hold a current Pennsylvania Registered Nurse license and have a minimum of 6 months of nursing experience. A BSN is preferred, and the role requires the ability to work flexible shifts in a fast-paced clinical environment.

Qualifications

Education
Bachelor degree

Key Skills

Patient advocacyBispecific therapy administrationClinical assessmentPatient educationSafety management

Oncology — Registered Nurse Career Context

Of the 50 active Registered Nurse listings this role was benchmarked against, 38% are remote, 60% have no call, 76% require no weekends.

Registered Nurse pay on WeekdayDoc is down 9.0% vs. the prior quarter (through Aug 2026).

The cost-of-living index for Pennsylvania is 97.6 (US average = 100; BEA Regional Price Parities (2024)). 61.7% of Pennsylvania clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).

Top Registered Nurse Jobs

40 matches · ranked by pay

Salary Distribution38 jobs · 34 employers

9
<$100k
9
$100k-120k
6
$120k-140k
8
$140k-160k
6
$160k+

Annual compensation range

Benefits & Perks37 jobs · 34 employers

401k / retirement match
86%
CME allowance
32%
Sign-on bonus
24%
Loan repayment
3%
Relocation assistance
3%

Share of similar jobs offering each benefit

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#3

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+ 38 more · ranked by pay

Work-life snapshot

median 5.1this job 2.8
Better work-life than 20% of Oncology (RN) listings

Listing-based score, 0–10, across 283 comparable listings. Shaded area = the share scoring below this one.

Living in Harrisburg

Typical 3-bedroom home value
$268k
Typical market rent
$1,369/mo
Residents’ average commute
20 min
Metro price indexU.S. average = 100
98.7
State income tax
Up to 3.1%
Sources & methodology

Sources: Zillow home values (Aug 2026), Zillow market rents (Aug 2026), U.S. Census ACS 2024 five-year.

BEA 2024 · Harrisburg-Carlisle, PA metro prices. Housing figures are city-level.

City-level figures. Not a cost-of-living guarantee.

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About UPMC

Hospitals and Health Care
Pittsburgh, PA
10,000+ employees

Benefits & Perks

Flexible scheduling
Professional development opportunities