Pays $318k-$388k — Pharmacovigilance market median is ~$300k (298 jobs)
Senior Director, Global Safety Physician
About the Role
Senior Director, Global Safety Physician at Madrigal Pharmaceuticals. Conshohocken, PA. $318K-$388K. Flexible PTO.
Join Madrigal Pharmaceuticals as a Senior Director, Global Safety Physician in Conshohocken, Pennsylvania, United States.
Benefits & Compensation
- Salary: $318K - $388K
- Flexible paid time off
- Medical, dental, vision insurance
- Life/disability insurance
- 401(k) with employer match
- Equity
- Mental health benefits
Work Schedule
- Full-Time position.
- Flexible scheduling available.
Apply to join Madrigal Pharmaceuticals as a Senior Director, Global Safety Physician.
Key Responsibilities
The Senior Director, Global Safety Physician provides medical oversight for clinical safety signals and leads benefit-risk assessments for investigational and marketed products. They also author critical regulatory documents and collaborate cross-functionally to ensure safety data quality and regulatory compliance.
Requirements
Candidates must hold an MD or equivalent medical degree with 15+ years of relevant experience in industry, clinical safety, or pharmacovigilance. Deep knowledge of global regulatory safety expectations, GCP, and experience with safety database systems is required.
Qualifications
- Education
- Doctoral or professional degree (postgraduate degree)
- Experience
- 10+ years of experience
Key Skills
Pharmacovigilance — Physician Career Context
In Pennsylvania, the Physician weighted monthly median benchmark on WeekdayDoc is ~$352k (443 salary observations; 1,235 listings), vs ~$290k nationally (10,075 salary observations; 25,331 listings). Monthly aggregates cover 2025-11-01 through 2026-09-01; these are not the modal's selected comparable-job medians.
Physician pay on WeekdayDoc is up 9.1% vs. the prior quarter (through Aug 2026).
The cost-of-living index for Pennsylvania is 97.6 (US average = 100; BEA Regional Price Parities (2024)), so the posted ~$353k midpoint carries the purchasing power of roughly $362k in an average-cost state. 61.7% of Pennsylvania clinicians report burnout symptoms in WeekdayDoc's Burnout Index (2026-01 data).
Position Insights
AI ANALYSISThis role scores 2.8/10 on work-life balance for Pharmacovigilance roles.
Career trajectory: This position offers advancement within 2-3 years. The compensation analysis shows this employer pays...
Benefits analysis: Compared to 298 similar roles, this listing's benefits package ranks...