Director, Drug Safety Physician

WeekdayDoc's proprietary algorithm rates Director, Drug Safety Physician at Spyre Therapeutics a 6.0 out of 10 for work-life balance — classified as good. This places the position in the top 35% of all Drug Safety/Pharmacovigilance physician listings evaluated on our platform. Contributing factors include no on-call duties, no weekend requirements, remote work flexibility.

This score reflects a generally positive work environment with some areas for improvement. Clinicians should evaluate scheduling and workload expectations carefully.

This Drug Safety/Pharmacovigilance position at Spyre Therapeutics is open to physician candidates.

Physicians (MD/DO) are in high demand across healthcare settings, with growing interest in positions that offer sustainable schedules and reduced administrative burden.

Remote physician positions in Drug Safety/Pharmacovigilance have grown significantly in recent years, offering clinicians the ability to maintain a full patient panel without geographic constraints or commute-related burnout.

Spyre Therapeutics lists compensation for this physician position at $280k to $315k annually.

This is a fully remote physician position. Remote clinicians can practice from any state where they hold an active license, eliminating commute time and offering maximum schedule flexibility. Many remote healthcare positions also allow providers to establish a more sustainable long-term practice pattern.

Key skills and qualifications: Drug safety, Pharmacovigilance, Medical review, ICSR review, Signal detection, Risk management, Clinical trial document review, Regulatory compliance. Candidates with experience in these areas may be especially well-suited for this Drug Safety/Pharmacovigilance role.

Core responsibilities: The Director, Drug Safety Physician will lead medical review of Individual Case Safety Reports and oversee safety surveillance, signal detection, and risk management strategies. They will also contribute to clinical trial documentation, regulatory filings, and cross-functional safety management team...

Benefits package: Market competitive compensation and benefits, Performance bonus, Equity grant opportunities, Health, welfare & retirement benefits, Unlimited PTO, Two company-wide shutdowns each year, Professional development opportunities, Remote working environment. A comprehensive benefits package is an important factor in evaluating total compensation beyond base salary.